How to prevent fatigue in metastatic colorectal cancer patients undergoing chemotherapy? Fatigue trajectories and psychosocial factors

摘要

Background: The colorectal cancer (CCR) is the 2nd most frequent cancer in women, the 3rd in men and the second cause of death by cancer in France. Cancer-Related Fatigue (CRF) is a hopeless, persistent and subjective feeling of fatigue in connection with treatments, but there is a significant link between psychosocial factors and severe fatigue in cancer patients. Objective: To identify fatigue trajectories in metastatic CCR patients undergoing chemotherapy. Our study will also aim in identifying the psychosocial determiners that may have an impact on fatigue evolution: emotional distress, control, coping and social support. 3 trajectories will reflect the different evolution of fatigue. We believe that a poor psychological adjustment to the disease, may contribute to an increase of fatigue over time.