The British Menopause Society & Women's Health Concern 2016 recommendations on hormone replacement therapy in menopausal women

摘要

The British Menopause Society (BMS) & Women's Health Concern 2016 recommendations on hormone replacement therapy (HRT) provide updated guidance based on recently published literature since the previous edition. The key data included in these updated recommendations include the cumulative long-term follow up outcomes from the Women's Health Initiative trial (WHI) that were published in 2013 and their practical significance. These recommendations also provide updated guidance relating to the changes in clinical practice post-WHI including the cardiovascular 'timing hypothesis' and 'window of opportunity', the role of transdermal administration of estradiol as well as that of micronised progesterone in this context. Our key recommendation is that all women should be able to access advice on how they can optimise their menopause transition and the years beyond. There should be a holistic and individualised approach in assessing women, with particular reference to lifestyle advice and diet modification. This should be an opportunity to discuss the advantages and disadvantages of their management options including HRT and complementary therapies. An extensive reference section and links to useful websites provide an opportunity to access evidence-based information in each key area.