Possibilities of Application of Low-Temperature Air Pressure in the Treatment of Burn Wounds

摘要

We present results of an experimental evaluation of implementation effectiveness of low-temperature air plasma of an atmospheric pressure arc discharge for treatment of third-degree skin burns in laboratory rats. Thermal skin burns were produced by our own original method, and efficacy was assessed daily. We found that the use of low-temperature air plasma of an atmospheric pressure arc discharge permits accelerated final wound healing by 49% (p < 0.05) and reduces incidence of purulent inflammation by 45.5% (p < 0.01). According to a March 2018 World Health Organization assessment, 180,000 annual deaths are the result of burns, with the vast majority of events occurring in low- and middle-income countries. Nonfatal burn injuries occur mainly at home and in the workplace and are one of the main causes of morbidity. The provision of assistance to this category of victims requires a multidisciplinary approach, taking into account pathogenesis of burn disease and features of the wound process that are typical for this type of damage. A system of active surgical treatment for seriously ill persons is recognized as generally accepted, but this approach has a number of disadvantages including a relatively high frequency of lysis with autodermotransplants, inevitability of long-term treatment and frequent dressings under anesthesia, high incidence of local and common infectious complications and duration of the rehabilitation period.