Polymorphic and Covalent Transformations of Gabapentin in Binary Excipient Mixtures after Milling-Induced Stress

Tinmanee Radaduen; Stamatis Stephen D.; Ueyama Eji; Morris Kenneth R.; Kirsch Lee E.

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Polymorphic and Covalent Transformations of Gabapentin in Binary Excipient Mixtures after Milling-Induced Stress

机译：碾压诱导应力后二元赋形混合物在二元赋形混合物中的多态性和共价转化

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Purpose The purpose of the research described herein was to develop a kinetic model for quantifying the effects of conditional and compositional variations on non-covalent polymorphic and covalent chemical transformations of gabapentin.

机译：目的本文所述的研究目的是开发一种动力学模型，用于量化条件和组成变化对加巴普丁的非共价多态性和共价化学转化的影响。

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来源
《Pharmaceutical research》 |2018年第2期|共12页
作者
Tinmanee Radaduen; Stamatis Stephen D.; Ueyama Eji; Morris Kenneth R.; Kirsch Lee E.;
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作者单位

Univ Iowa Div Pharmaceut &

Translat Therapeut Coll Pharm Iowa City IA 52242 USA;

Eli Lilly &

Co Lilly Res Labs Small Mol Design &

Dev Indianapolis IN 46285 USA;

Daiichi Sankyo Pharmaceut Technol Div Analyt &

Qual Evaluat Res Labs Hiratsuka Kanagawa 2540014;

Long Isl Univ Arnold &

Marie Schwartz Coll Pharm &

Hlth Sci Lachman Inst Pharmaceut Anal;

Univ Iowa Div Pharmaceut &

Translat Therapeut Coll Pharm Iowa City IA 52242 USA;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
chemical stability; excipients; milling; physical stability; polymorphism;

机译：化学稳定性;赋形剂;铣削;物理稳定;多态性;

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2. Polymorphic and Covalent Transformations of Gabapentin in Binary Excipient Mixtures after Milling-Induced Stress [J] . Tinmanee Radaduen, Stamatis Stephen D., Ueyama Eji, Pharmaceutical research . 2018,第2期

机译：碾压诱导应力后二元赋形混合物在二元赋形混合物中的多态性和共价转化
3. Screening for Excipients Probing Polymorphic Phase Transformations by Raman Spectroscopy [J] . T. Rades Screening Trends in Drug Discovery . 2006,第3期

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4. Role of Excipients on N-Oxide Raloxifene Generation from Raloxifene-Excipients Binary Mixtures [J] . Sanjeeva YARKALA, Sivakumar AMARAVADI, Vinay U. RAO, Chemical and Pharmaceutical Bulletin . 2009,第10期

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5. Mechanical properties of compacts made with binary mixtures of pharmaceutical excipients of three different kinds [C] . Virginie Busignies, Pierre Evesque, Patrice Porion, International Conference on Micromechanics of Granular Media . 2009

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Polymorphic and Covalent Transformations of Gabapentin in Binary Excipient Mixtures after Milling-Induced Stress

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