Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo

Maki-Opas I.; Hamalainen M.; Moilanen L.; Ahonen T. J.; Haavikko R.; Moreira V. M.; Muraki K.; Yli-Kauhaluoma J.; Moilanen E.

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Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo

机译：吡嗪稠合的三萜类化合物在体外阻塞瞬时受体潜在的肛门蛋白-1（TRPA1）离子通道，并抑制体内TRPA1介导的急性炎症

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来源
《Scandinavian journal of rheumatology》 |2017年第5期|共1页
作者
Maki-Opas I.; Hamalainen M.; Moilanen L.; Ahonen T. J.; Haavikko R.; Moreira V. M.; Muraki K.; Yli-Kauhaluoma J.; Moilanen E.;
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作者单位

Univ Tampere Fac Med &

Life Sci Immunopharmacol Res Grp Tampere Finland;

Univ Tampere Fac Med &

Life Sci Immunopharmacol Res Grp Tampere Finland;

Univ Tampere Fac Med &

Life Sci Immunopharmacol Res Grp Tampere Finland;

Univ Helsinki Div Pharmaceut Chem &

Technol Fac Pharm Helsinki Finland;

Univ Helsinki Div Pharmaceut Chem &

Technol Fac Pharm Helsinki Finland;

Univ Helsinki Div Pharmaceut Chem &

Technol Fac Pharm Helsinki Finland;

Aichi Gakuin Univ Sch Pharm Lab Cellular Pharmacol Nagoya Aichi Japan;

Univ Helsinki Div Pharmaceut Chem &

Technol Fac Pharm Helsinki Finland;

Univ Tampere Fac Med &

Life Sci Immunopharmacol Res Grp Tampere Finland;

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正文语种 eng
中图分类免疫性疾病;
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1. Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo [J] . Maki-Opas I., Hamalainen M., Moilanen L., Scandinavian journal of rheumatology . 2017,第5期

机译：吡嗪稠合的三萜类化合物在体外阻塞瞬时受体潜在的肛门蛋白-1（TRPA1）离子通道，并抑制体内TRPA1介导的急性炎症
2. Transient receptor potential ankyrin-1 (TRPA1) as a novel factor in osteoarthritis: TRPA1 ion channel mediates monosodium iodoacetate (MIA)-induced acute inflammation and contributes to the development of cartilage degradation and joint pain in the MIA model of osteoarthritis [J] . Moilanen L. J., Hamalainen M., Nummenmaa E., Scandinavian journal of rheumatology . 2018,第Suppla129期

机译：瞬态受体潜在的肛门蛋白-1（TRPA1）作为骨关节炎的新因素：TRPA1离子通道介导单钠碘酸钠（MIA） - 诱导急性炎症，有助于开发骨关节炎的MIA模型中的软骨降解和关节疼痛
3. Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo [J] . Moriello Aniello Schiano, Luongo Livio, Guida Francesca, CNS & neurological disorders drug targets . 2016,第8期

机译：查尔酮衍生物激活和脱敏瞬态潜在的锚蛋白1阳离子通道，亚家族A，成员1 TRPA1离子通道：体外的结构活性关系和体内的抗伤害和抗炎活性。
4. Validation of Chemiluminescent Reporting of Leukocyte Respiratory Burst Response in vitro as an Accurate Predictor of Material Induced Acute Inflammation in vivo [C] . Nicholas Bryan, Helen Ashwin, Yves Bayon, World biomaterials congress . 2012

机译：化学发光报告白细胞呼吸爆发反应的体外验证，作为体内材料诱发急性炎症的准确预测指标
5. The effects of volatile general anesthetics on TRPV1 and TRPA1, two transient receptor potential ion channels in the peripheral pain transduction pathway [D] . Cornett, Paul Matthew 2006

机译：挥发性全身麻醉药对外周痛转导通路中两个瞬时受体电位离子通道TRPV1和TRPA1的影响
6. Characterization of Transient Receptor Potential Vanilloid-1 (TRPV1) Variant Activation by Coal Fly Ash Particles and Associations with Altered Transient Receptor Potential Ankyrin-1 (TRPA1) Expression and Asthma [O] . Cassandra E. Deering-Rice, Chris Stockmann, Erin G. Romero, 2016

机译：粉煤灰颗粒对瞬态受体电位Vanilloid-1（TRPV1）变异激活的表征以及与瞬态受体电位锚蛋白1（TRPA1）表达和哮喘的关联
7. Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo [O] . Ilari Mäki-Opas, Mari Hämäläinen, Lauri J. Moilanen, 2019

机译：吡嗪 - 融合的三萜类化合物在体外阻断TRPA1离子通道并抑制体内抑制TRPA1介导的急性炎症

Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo

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