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Different absorption and metabolism of ginsenosides after the administration of total ginsenosides and decoction of Panax ginseng Panax ginsengPanax ginseng

机译：总人参皂苷和煎剂施用后的人参皂苷的不同吸收和代谢 panax ginseng panax ginseng Panax人参

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Rationale > <fc> <fi>Panax ginseng</fi> </fc> C.A. Meyer (PG), which contains polysaccharides and ginsenosides as the major bioactive components, has been used to promote health and treat diseases for thousands of years in China. Total ginsenosides were extracted from a decoction of <fc> <fi>Panax ginseng</fi> </fc> (GD), which included both ginsenosides and polysaccharides, and dissolved in water to obtain a total ginsenosides aqueous solution (TGAS). To study their absorption and metabolism, the pharmacokinetics (PK) and metabolites of ginsenosides in vivo were investigated after the administration of GD and TGAS. </section> <section numbered="no" xml:id="rcm8788-sec-0002"> <title type="main">Methods >Rat and mice plasma samples were collected after the administration of GD and TGAS. Ultra‐performance liquid chromatography coupled with time‐of‐flight mass spectrometry was used with the UNIFI platform to identify metabolites in the plasma sample. The pharmacokinetic parameters were calculated using a noncompartmental method in the Drug and Statistics software package. </section> <section numbered="no" xml:id="rcm8788-sec-0003"> <title type="main">Results > Thirty ginsenoside metabolites were identified in mice plasma, of which only seven were found in the rat plasma after the administration of GD. The PK of ginsenosides Rb <sub>1</sub> , Rc, and Rd were also determined after the oral administration of GD and TGAS and showed significant differences in the pharmacokinetic parameters. </section> <section numbered="no" xml:id="rcm8788-sec-0004"> <title type="main">Conclusions > There was no difference in the biotransformation pathways after the oral administration of GD and TGAS, indicating that there was no influence of polysaccharides on the biotransformation of ginsenosides in vivo . However, the pharmacokinetic parameters were different after the administration of GD and TGAS, possibly because of the polysaccharides in GD. This study should be of significance in exploring the basis of PG bioactivities and lays the foundation for the further development of new drugs using PG. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <sec numbyed =“no”xml：id =“rcm8788-sec-0001”> <标题类型=“main”>基本原理</ title> > <FC> <fi> panax ginseng </ fi> </ FC> C.A.含有多糖和人参皂苷作为主要生物活性成分的Meyer（PG）已被用于促进中国数千年的健康和治疗疾病。从汤中提取总芽孢杆菌 <FC> <fi> panax ginseng </ fi> </ FC> （GD）包括人参皂苷和多糖，并溶解在水中以获得总花生皂苷水溶液（TGA）。研究他们的吸收和新陈代谢，药代动力学（PK）和人参皂苷代谢物在体内</ i> 在给予GD和TGA后研究。 </ p> </部分> <secto numbyed =“no”xml：id =“rcm8788-sec-0002”> <标题类型=“main”>方法</ title> 在给予Gd和Tgas后收集大鼠和小鼠等离子体样品。与飞行时间质谱法相结合的超高性能液相色谱与UNIFI平台一起使用以鉴定等离子体样品中的代谢物。药代动力学参数使用在药物和统计软件包中的非组分方法计算。</ p> </部分> <sec numbyed =“no”xml：id =“rcm8788-sec-0003”> <标题类型=“main”>结果</ title> > 在小鼠血浆中鉴定了三十个月状代谢物，其中在给予Gd后大鼠血浆中仅发现七个。人参皂甙rb <sub> 1 </ sub> ，RC和Rd也在口服施用Gd和TGA后确定，并且在药代动力学参数中显示出显着差异。 </ p> </部分> <secto numbyed =“no”xml：id =“rcm8788-sec-0004”> <标题类型=“main”>结论</ title> > 在Gd和TGA的口服施用后生物转化途径没有差异，表明多糖对人参皂苷的生物转化没有影响在体内</ i> 。然而，药代动力学参数在施用Gd和TGA后不同，可能是因为GD中的多糖。本研究应具有重要意义，探索PG生物活像的基础，并为使用PG奠定了进一步发展新药的基础。 </ p> </部分> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-26627/'>《Rapid Communications in Mass Spectrometry: RCM》</a> <b style="margin: 0 2px;">|</b><span>2020年第13期</span><b style="margin: 0 2px;">|</b><span>共12页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1187.html" title="分析化学">分析化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" 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Chi.KT</a> <span> <a href="/journal-cn-7339/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 特产研究 </a> </span> <span> . 1999</span><span>,第003期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_seed_thesis/0201258979964.html">后熟阶段的人参（Panax ginseng C.A.Mey）种子对脱水和贮存温度的反应</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张志娥&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张志娥</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=石思信&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,石思信</a> <span> <a href="/journal-cn-6863/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 种子 </a> </span> <span> . 1999</span><span>,第001期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_detail_thesis/0201294239647.html">Creation of Virtual Wi-Fi Access Point and Secured Wi-Fi Pairing, through NFC</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Oussama Stiti&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Oussama Stiti</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Othmen Braham&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Othmen Braham</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guy Pujolle&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Guy Pujolle</a> <span> <a href="/journal-cn-56342/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 通讯、网络与系统学国际期刊（英文） </a> </span> <span> . 2014</span><span>,第6期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-32702_thesis/02022659944.html">光化学降解人参（Ｐａｎａｘｇｉｎｓｅｎｇ）中六氯苯（ＢＨＣ）残留的研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 孙强</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=孙德岭&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,孙德岭</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张振宇&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张振宇</a> <span> <a href="/conference-cn-32702/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国环境科学学会成立20周年大会 </a> <span> <span> . 1999</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020312771125.html">人参（Panax ginseng）和西洋参（Panax quinquefolius）copia-like反转录转座子反转座酶序列的克隆和分析</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘晓冬&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘晓冬</a> <span> . 2005</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120107585406.html">药用植物人参(panax ginseng)气候特征曲线</a> <b>[P]</b> . <span> 中国专利： CN105095647A </span> <span> . 2015-11-25</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120917049.html">表现出人参花(Panax ginseng C.A.Meyer)的香味的香料组合物</a> <b>[P]</b> . <span> 中国专利： CN101861137B </span> <span> . 2012.03.21</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130405557400.html">EXTRACT OF PANAX GINSENG INCLUDING WILD GINSENG OR GINSENG, CONTAINING RARE GINSENOSIDES IN HIGH QUNATITY, PLANT STEM CELL DERIVED FROM CAMBIUM OF PANAX GINSENG, OR METHOD FOR PREPARING EXTRACT THEREOF</a> <b>[P]</b> . <span> 外国专利：  EP3184628B1 </span> <span> . 2019-07-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人参提取物，包括野生人参或高人参，包含高定量的稀有人参皂甙，由人参钙衍生的植物干细胞，或制备其的方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130408207065.html">EXTRACT OF PANAX GINSENG INCLUDING WILD GINSENG OR GINSENG, CONTAINING RARE GINSENOSIDES IN HIGH QUNATITY, PLANT STEM CELL DERIVED FROM CAMBIUM OF PANAX GINSENG, OR METHOD FOR PREPARING EXTRACT THEREOF</a> <b>[P]</b> . <span> 外国专利：  EP3184628A4 </span> <span> . 2018-04-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人参提取物，包括野生人参或高人参，包含高定量的稀有人参皂甙，由人参钙衍生的植物干细胞，或制备其的方法 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130409339189.html">EXTRACT OF PANAX GINSENG INCLUDING WILD GINSENG OR GINSENG, CONTAINING RARE GINSENOSIDES IN HIGH QUNATITY, PLANT STEM CELL DERIVED FROM CAMBIUM OF PANAX GINSENG, OR METHOD FOR PREPARING EXTRACT THEREOF</a> <b>[P]</b> . <span> 外国专利：  IN201747006967A </span> <span> . 2017-04-21</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：人参提取物，包括野生人参或高人参，包含高定量的稀有人参皂甙，由人参钙衍生的植物干细胞，或制备其的方法 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704024019995','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 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