Selective spectrofluorimetric method for determination of Lisinopril in pharmaceutical preparations and in presence of hydrochlorothiazide: Application to content uniformity testing

Derayea Sayed M.; Badr El‐Din Khalid M.; Mohammed Fatma F.

摘要

Abstract > A novel sensitive and cost‐effective spectrofluorimetric method has been developed and validated for determination of lisinopril (an angiotensin converting enzyme inhibitor) in its pure form and pharmaceutical preparations. The method is based on the reaction of the drug with ninhydrin and phenylacetaldehyde in buffered medium (pH?7.0) to form a highly fluorescent product measured at 460?nm after excitation at 390?nm. Different experimental parameters were optimized and calibration curve was constructed. The fluorescence‐concentration relationship was linear in the range of 0.15–4.0?μg mL ?1 . The calculated Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.04 and 0.12?μg mL ?1 , respectively. The method was successfully applied for the analysis of pharmaceutical preparations containing the studied drug either alone or co‐formulated with hydrochlorothiazide. The obtained results were in agreement with those of the reported method in respect to accuracy and precession. Moreover, the method was applied content uniformity testing according to United States Pharmacopeia (USP) guidelines. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >一种新颖的敏感和经济高效的光谱氟化物方法已经开发并验证了Lisinoplil的测定（血管紧张素转化酶抑制剂）纯度和药物制剂。该方法基于药物与茚三酮和苯基乙醛在缓冲培养基（pH·7.0）中的反应，以在390℃激发后在460℃下测量的高度荧光产物。优化不同的实验参数，构建校准曲线。荧光浓度关系在0.15-4.0×μgml α1</ sup>的范围内。计算的检测极限（LOD）和定量极限（LOQ）分别为0.04和0.12？μgmL Δ1/ sup>。该方法成功地应用于分析含有所研究的药物的药物制剂，可以单独或共同配制氢氯噻嗪。获得的结果与报告的方法达成协议，就准确性和预防。此外，根据美国药典（USP）指南，该方法是应用含量均匀性测试。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-26441/'>《Luminescence: The journal of biological and chemical luminescence》</a> <b style="margin: 0 2px;">|</b><span>2017年第8期</span><b style="margin: 0 2px;">|</b><span>共6页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Derayea Sayed M.&option=202" target="_blank" rel="nofollow">Derayea Sayed M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Badr El‐Din Khalid M.&option=202" target="_blank" rel="nofollow">Badr El‐Din Khalid M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mohammed Fatma F.&option=202" target="_blank" rel="nofollow">Mohammed Fatma F.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Analytical Chemistry Department Faculty of PharmacyMinia UniversityMinia Egypt;</p> <p>Analytical Chemistry Department Faculty of PharmacyMinia UniversityMinia Egypt;</p> <p>Analytical Chemistry Department Faculty of PharmacyMinia UniversityMinia Egypt;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/1345.html" title="生物光学">生物光学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=lisinopril&option=203" rel="nofollow">lisinopril;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ninhydrin&option=203" rel="nofollow">ninhydrin;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=pharmaceutical analysis&option=203" rel="nofollow">pharmaceutical analysis;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=spectrofluorimetry&option=203" rel="nofollow">spectrofluorimetry;</a> </p> <div class="translation"> 机译：LISINOPLIL;茚三酮;药物分析;光谱氟位物; 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tuijian_authcolor">,周绍波</a> <span> <a href="/conference-cn-62111/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第一届全国水泥质量控制技术论坛 </a> <span> <span> . 2017</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313525868.html">原子吸收光谱法测定人发中微量元素的方法研究及自闭症患儿头发中微量元素含量的测定与比较</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=解蕾&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 解蕾</a> <span> . 2010</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113715694.html">一种气相色谱测定聚烯丙胺盐酸盐中烯丙胺盐酸盐单体含量的方法</a> <b>[P]</b> . <span> 中国专利： CN113884608A </span> <span> . 2022-01-04</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120105191533.html">借助测量光谱与参照光谱的互相关来测定均匀分布在介质中的化学物质的存在的方法</a> <b>[P]</b> . <span> 中国专利： CN1989408A </span> <span> . 2007-06-27</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130435169137.html">A POLYPEPTIDE CODING MOLECULE OF THE NUCLEIC ACID, HUMAN GROWTH PROTEIN CODED BY THE DNA MOLECULE, HUMAN GROWTH PROTEIN CODING CDNA, PHARMACEUTICAL COMPOUND, APPLICATION OF HUMAN GROWTH PROTEIN AND THE DNA SEQUENCE, METHOD FOR THE DETERMINATION OF THE LOW GROWTH, METHOD FOR THE IDENTIFICATION OF THE GENETIC DEFECT, CELLS TRANSFORMED BY THE DNA SEQUENCE, TESTING SYSTEM AND METHOD FOR THE IDENTIFICATION OR SCREENING TESTS, EXPRESSION VECTOR AS WELL AS APPLICATION OF THE HUMAN GROWTH PROTEINS</a> <b>[P]</b> . <span> 外国专利：  PL194248B1 </span> <span> . 2007-05-31</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：核酸的多肽编码分子，由DNA分子编码的人类生长蛋白质，人类生长蛋白质编码CDNA，药物化合物，人类生长蛋白质和DNA序列的应用，低生长度的测定方法，方法基因缺陷，DNA序列转化的细胞，鉴定或筛选试验的表达系统和方法，表达载体以及人类生长蛋白的应用 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130450880485.html">Process for producing a Pharmaceutical Combination containing carvedilol and Hydrochlorothiazide or Salts and additivesComprising: (a) pressed to form a Mass that contains both carvedilol and Hydrochlorothiazide, granular, with a Moisture content of 6 - 20, and bulk density of 0.1 - 1.5 g / ml and (b) to compress.</a> <b>[P]</b> . <span> 外国专利：  CL1999002737A1 </span> <span> . 2000-10-24</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含卡维地洛和氢氯噻嗪或盐和添加剂的药物组合的生产方法包括：（a）压制成含有卡维地洛和氢氯噻嗪的颗粒状物料，其水分含量为6-20％，堆积密度为0.1-1.5 g / ml和（b）压缩。 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130440007379.html">METHOD FOR MANUFACTURE OF INTERLEUKINE-2- FOR PHARMACEUTICAL APPLICATIONS, METHOD FOR MANUFACTURE OF PREPARATION, PREPARATION CONTAINING INTERLEUKINE-2, FREEZE-DRIED PREPARATION, FREEZE-DRIED PHARMACEUTICAL PREPARATION, HYDROUS PHARMACEUTICAL PREPARATION, A SET, APPLICATION OF MICRO-AGGREGATES, APPLICATION OF THE PREPARATION, APPLICATION OF THE SECOND PHARMACEUTICAL COMPOUND</a> <b>[P]</b> . <span> 外国专利：  PL372651A1 </span> <span> . 2005-05-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：Interleukine-2的制造方法，用于制药的方法，制备方法，包含Interleukine-2的制备，冷冻干燥的制剂，冷冻干燥的药物制备，水化药物制备，一套，微农药的应用第二种药物的制备，应用 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" 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