Instrument Considerations in the Transfer of Chromatographic Methods, Part I: Method Considerations

摘要

Successful transfer of chromatographic methods often proves more challenging than expected. This three-part article series will summarize the details of this process with particular attention to the sources of confusion and to some suggested solutions for the observed difficulties. In part I, the focus will be on the method as a whole and considerations for avoiding and eliminating ambiguities and inconsistencies between laboratories. In part II, the characterization of the system will be emphasized. In part III, emphasis will be placed the techniques for bringing the modules of the two systems into alignment.