A chemoselective synthesis and biological evaluation of novel benzo[g]thiazolo[3,2-a]quinolone derivatives

摘要

A novel approach for chemoselective synthesis of functionalized benzo[g]thiazolo[3,2-a]quinolones from dithioacetals, cysteamine hydrochloride, 2-hydroxy-1,4-naphthoquinone, and aromatic aldehydes in ethanol is described. All products were tested in vitro for their cytotoxic effects on lung, breast, and prostate cancer cells.