Validation of SmartPill ? ? wireless motility capsule for gastrointestinal transit time: Intra‐subject variability, software accuracy and comparison with video capsule endoscopy

摘要

Abstract Background There is interest in ultimately combining endoscopy and motility assessments. Gastric emptying ( GET ), small bowel ( SBTT ), colon ( CTT ) and whole gut transit ( WGTT ) times are conveniently obtained by SmartPill ? wireless motility capsule ( WMC ) that records luminal pH , temperature and pressure. Reproducibility within same subjects and accuracy of software derived times (Motili GI ? ) were investigated for diagnostic application. GET and SBTT were separately measured using video capsule endoscopy ( VCE ). The aim of this investigation was to assess same subject reproducibility of WMC , accuracy of software derived transit times and relate to Pillcam ? SB (small bowel) VCE motility data. Methods Seventy three healthy adults ingested a 260?kcal mixed meal followed by WMC tests. Food intake was permitted after 6?hours. Regional transit data was obtained for GET , SBTT and CTT , the sum yielding WGTT . Nineteen subjects repeated WMC tests 2 or 4?weeks later; a separate 70 underwent VCE while fasted. Key Results Visually derived data from WMC yielded GET 3.46±0.27, SBTT 5.15±0.21, CTT 20.76±1.19 and WGTT 29.53±1.28?hours (mean± SEM ). Pearson's correlation coefficients ( r ) against software derived results were: GET 0.78 ( P .0001), SBTT 0.28 ( P .05), CTT 0.96 ( P .0001), WGTT 0.99 ( P .0001). VCE yielded lower GET (0.71±0.08?hours) and SBTT (4.15±0.13?hours). Conclusions and Inferences GET , SBTT , CTT and WGTT obtained by WMC are commensurate with literature values, including by other methods. Visually and software derived transit times have strongest correlations for CTT and WGTT . WMC yields longer GET and SBTT than VCE , perhaps due to meal related effects on motility.