Good clinical results but moderate osseointegration and defect filling of a cell-free multi-layered nano-composite scaffold for treatment of osteochondral lesions of the knee

摘要

Abstract Purpose The aim of this retrospective study was to evaluate the clinical and radiological results of a nano-composite multi-layered three-dimensional biomaterial scaffold for treatment of osteochondral lesions (OCL) of the knee. It was a particular radiological interest to analyse the osseointegration, filling of the defects and the bone tracer uptake (BTU), and it was hypothesised that this scaffold, which was created to mimic the entire osteo-cartilaginous unit, is integrated within the bone 12?months postoperatively and comes along with improved patients symptoms and function. Methods Fourteen patients (male:female?=?11:3, mean age?±?SD 33.1?±?10.7?years) treated for OCL (size 1.0–3.5?cm_(2)) were clinically and radiologically evaluated at 1?year postoperatively. The data were prospectively collected including SPECT/CT, Tegner and Lysholm scores. BTU was anatomically localised and volumetrically quantified in SPECT/CT. Defect filling was analysed in CT. Spearman’s rho and Wilcoxon test were used for correlation of BTU in SPECT/CT and clinical scores ( p ? Results A significant improvement in Lysholm knee score ( p ? p ? p ? Conclusions Treatment of OCL in the knee joint with a nano-composite multi-layered three-dimensional biomaterial scaffold resulted in a significant clinical improvement at 1-year follow-up. However, osseointegration was still ongoing at 12-month follow-up. Level of evidence Case series, Level IV.