Modeling the target dose fall-off in IMRT and VMAT planning techniques for cervical SBRT

摘要

There has been growing interest in the use of stereotactic body radiotherapy (SBRT) technique for the treatment of cervical cancer. The purpose of this study was to characterize dose distributions as well as model the target dose fall-off for intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) delivery techniques using 6 and 10 MV photon beam energies. Fifteen (n = 15) patients with non-bulky cervical tumors were planned in Pinnacle(3) with a Varian Novalis Tx (HD120 MLC) using 6 and 10 MV photons with the following techniques: (1) IMRT with 10 non-coplanar beams (2) dual, coplanar 358 degrees VMAT arcs (4 degrees spacing), and (3) triple, non-coplanar VMAT arcs. Treatment volumes and dose prescriptions were segmented according to University of Texas Southwestern (UTSW) Phase II study. All plans were normalized such that 98% of the planning target volume (PTV) received 28 Gy (4 fractions). For the PTV, the following metrics were evaluated: homogeneity index, conformity index, D-2c, D-mean, D-max, and dose fall-off parameters. For the organs at risk (OARs), D-2cc, D-15cc, D-0.01cc, V-20, V-40, V-50, V-60, and V-80 were evaluated for the bladder, bowel, femoral heads, rectum, and sigmoid. Statistical differences were evaluated using a Friedman test with a significance level of 0.05. To model dose fall-off, expanding 2-mm-thick concentric rings were created around the PTV, and doses were recorded. Statistically significant differences (p 0.05) were noted in the dose fall-off when using 10 MV and VMAT(3-arc), as compared with IMRT. VMAT(3-arc) improved the bladder V-40, V-50, and V-60, and the bowel V-20 and V-50. All fitted regressions had an R-2 = 0.98. For cervical SBRT plans, a VMAT(3-arc) approach offers a steeper dose fall-off outside of the target volume. Faster dose fall-off was observed in smaller targets as opposed to medium and large targets, denoting that OAR sparing is dependent on target size. These improvements are further pronounced with the use of 10-MV photons. Published by Elsevier Inc. on behalf of American Association of Medical Dosimetrists.