Synthesis, Characterization and in vitro Drug Release Studies of Sonolytically Intercalated Poly(o-anisidine)/Montmorillonite Nanocomposites

摘要

In the present study, in situ intercalation and polymerization of o-anisidine within montmorillonite (MMT) clay was carried out via ultrasonication using different loadings of o-anisidine (12.5 wt%, 25 wt%, and 50 wt%). Infrared (IR) spectra indicated successful incorporation of poly(o-anisidine) (PAnis) in MMT. Ultraviolet (UV)-visible spectra confirmed the polaronic state of nanocomposites, while X-ray diffraction (XRD) analysis revealed intercalation of PAnis in the interlayer space of MMT. Transmission electron microscope (TEM) and optical micrographs showed nanomorphology of prepared nanocomposites. The nanocomposites were modified by loading with anti-migraine drug in different concentrations to investigate the adsorption profiles in gastric fluid (pH 1.2) and intestinal fluid (pH 7.4). The adsorption profiles followed the Langmuir isotherm. Release kinetics followed zero order model and parabolic diffusion model in gastric fluid (pH 1.2) and intestinal fluid (pH 7.4). The nanocomposites were found to show fast release behavior and hold potential to be used as an effective antidepressant drug delivery vehicle.