Palladium Catalyzed Amination of Aryl Chlorides: Development of Extremely Active Phosphine Ligands with Large Substrate Scope

摘要

Arylamines are important building blocks in many pharmaceuticals, natural products, agrochemicals and organic materials. In recent years, the palladium catalyzed C-N cross-coupling reaction (Buchwald-Hartwig amination) has become one of the most important synthetic method for their preparation. This development is mainly due to the improvements in the activity of the catalysts, which led to continuous improvements of the synthetic protocols.