Preparation of dual-targeted redox-responsive nanogels based on pegylated sorbitan for targeted and antitumor drug delivery

Sepideh Khoee; Goonay Yousefalizadeh; Alireza Kavand

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Preparation of dual-targeted redox-responsive nanogels based on pegylated sorbitan for targeted and antitumor drug delivery

机译：基于聚乙二醇化山梨糖醇的靶向和抗肿瘤药物递送的双靶向氧化还原纳米凝胶的制备

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?Pegylated sorbitan was linked to 3-aminopropyl triethoxysilane via Michael reaction.

?Fe3O4nanoparticles were prepared via co-precipitation method.

?Star-shaped PEG was grafted on the surface of iron oxide nanoparticles.

?Cystine cross-linked pegylated sorbitan was synthesized as redox sensitive carrier.

?Folic acid was conjugated on the polymer surface to make folate-mediated targeting.

Abstract

This work reports t

机译：<！[cdata [

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< CE：简单段ID =“SP0010”View =“全部”>

？ Pegymated Sorbetan通过Michael反应连接到3-氨基丙基三乙氧基硅烷。

？ Fe 3 O. 4 纳米粒子通过共沉淀法制制备。

？ < CE：PARA ID =“P0015”视图=“全部”>星形栓在氧化铁纳米粒子的表面上接枝。

？胱氨酸交联聚乙二醇化山梨糖醇被合成为氧化还原敏感载体。

？叶酸是在聚合物表面上缀合，使叶酸介导的靶向。

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此工作报告T

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来源
《European Polymer Journal》 |2017年第2017期|共14页
作者
Sepideh Khoee; Goonay Yousefalizadeh; Alireza Kavand;
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作者单位

Polymer Laboratory School of Chemistry College of Science University of Tehran;

Polymer Laboratory School of Chemistry College of Science University of Tehran;

Polymer Laboratory School of Chemistry College of Science University of Tehran;

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原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
Magnetic iron oxide nanoparticles; Redox-responsive; Pegylated sorbitan; Disulfide nanogel; Drug delivery applications; Dual-targeting;

机译：磁性氧化铁纳米颗粒;氧化还原响应;聚乙二醇化脱水山梨糖醇;二硫化物纳米凝胶;药物递送应用;双重针对性;

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1. Preparation of dual-targeted redox-responsive nanogels based on pegylated sorbitan for targeted and antitumor drug delivery [J] . Sepideh Khoee, Goonay Yousefalizadeh, Alireza Kavand European Polymer Journal . 2017,第期

机译：基于聚乙二醇化山梨糖醇的靶向和抗肿瘤药物递送的双靶向氧化还原纳米凝胶的制备
2. Multifunctional nanogel engineering with redox-responsive and AIEgen features for the targeted delivery of doxorubicin hydrochloride with enhanced antitumor efficiency and real-time intracellular imaging [J] . Ma Yuwei, Zhou Huiyi, Hu Fan, Artificial cells, nanomedicine, and biotechnology. . 2018,第Suppla3期

机译：多功能纳米凝胶工程与氧化还原响应和AIEGEN特征，具有增强的抗肿瘤效率和实时植物的盐酸多柔比星型盐酸盐和实时成像
3. Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: Synthesis, characterization, and antitumor activity in vitro and in vivo [J] . ChuanX., SongQ., LinJ., Molecular pharmaceutics . 2014,第10期

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机译：具有氧化还原响应性和AIEGEN特征的多功能纳米凝胶工程，具有增强的抗肿瘤效率和实时植物盐酸盐素的靶向递送和实时细胞内成像

Preparation of dual-targeted redox-responsive nanogels based on pegylated sorbitan for targeted and antitumor drug delivery

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