P-580: Exposure to Borrelia burgdorferi s.l and the risk of neuropsychiatric disorders and functional decline in older adults

摘要

Introduction: Exposure to B. burgdorferi s.l (BB) has been associated with neuropsychiatric disorders. The aim of the present study was to determine the relationship between previous exposure to BB with incidental neuropsychiatric disorders and functional decline among older farmers. Methodology: Ancillary study from the AMI cohort, constituted of 1002 farmers C 65 years-old in south-western France. Among 689 participants who consented a blood sample at baseline, BB serology was performed. After a 6-year follow-up, cognitive decline, incident dementia, depressive symptomatology, and functional status were determined. Results: Mean age was 75.8 (SD = 6.4). Seroprevalence rate of BB was 4.9%. At baseline, in comparison with BB- participants, BB + were older (p = 0.0285), predominantly men (p = 0.0005), and had lower CES-D scores (p = 0.0058). No other differences were found between groups. No relationship between seropositivity and studied outcomes over time were found, neither in the crude nor after adjusting for confounding variables. Excluding participants with prevalent dementia, no significant risk of incident dementia was found among BB + participants (non-adjusted HR = 0.65; 95% CI 0.24-1.76 and HR = 0.42; 95% CI 0.1-1.17 adjusted for diverse confounders). Conclusions: This is one of the few longitudinal studies conducted in order to establish the risk of neuropsychiatric disorders and functional decline associated with exposure to the etiologic agent of Lyme Disease (LD). Despite its limitations (lack of information if clinical manifestations of LD existed, date of exposition, treatment), this study suggests that exposure alone to BB is not a risk factor for said outcomes.