Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations

Barsotti Anthony M.; Ryskin Michael; Rollins Robert A.

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Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations

机译：实体瘤中的表观遗传重编程：EZH2功能突变的治疗意义

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来源
《Epigenomics》 |2015年第5期|共4页
作者
Barsotti Anthony M.; Ryskin Michael; Rollins Robert A.;
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作者单位

Pfizer Worldwide Res &

Dev Oncol Res Unit Pearl River NY 10965 USA;

Pfizer Worldwide Res &

Dev Oncol Res Unit Pearl River NY 10965 USA;

Pfizer Worldwide Res &

Dev Oncol Res Unit Pearl River NY 10965 USA;

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原文格式 PDF
正文语种 eng
中图分类遗传学;
关键词
epigenetic reprogramming; epigenetic therapy; EZH2; gain-of-function mutations; histone methylation; melanoma; polycomb;

机译：表观遗传重编程;表观遗传疗法;EzH2;功能性突变;组蛋白甲基化;黑素瘤;Polycomb;

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专利

1. Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations [J] . Barsotti Anthony M., Ryskin Michael, Rollins Robert A. Epigenomics . 2015,第5期

机译：实体瘤中的表观遗传重编程：EZH2功能获得性突变的治疗意义
2. Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors [J] . Huang Xun, Yan Juan, Zhang Min, Cell . 2018,第1期

机译：靶向表观遗传串像作为EZH2-异常实体瘤的治疗策略
3. Somatic Copy Number Amplification and Hyperactivating Somatic Mutations of EZH2 Correlate With DNA Methylation and Drive Epigenetic Silencing of Genes Involved in Tumor Suppression and Immune Responses in Melanoma [J] . Jessamy Tiffen, Stephen Wilson, Stuart J. Gallagher, Neoplasia: an international journal for oncology research . 2016,第2期

机译：EZH2的体细胞拷贝数扩增和多粘激活体细胞突变与参与黑素瘤中肿瘤抑制和免疫应答的基因的DNA甲基化和脱位诱导的脱节沉默
4. Exploring the role of EZH2 (PRC2) as epigenetic target [C] . Imlimaong Aier, Utkarsh Raj 2016 International Conference on Bioinformatics and Systems Biology . 2016

机译：探索EZH2（PRC2）作为表观遗传靶的作用
5. The role of mutational activation of RAS and PI3K signaling pathways in human tumors: Biologic and therapeutic implications. [D] . Halilovic, Ensar. 2009

机译：RAS和PI3K信号通路突变激活在人类肿瘤中的作用：生物学和治疗意义。
6. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth [O] . Anthony M. Barsotti, Michael Ryskin, Wenyan Zhong, 2015

机译：通过肿瘤来源的EZH2功能获得性突变进行表观遗传重编程可促进侵袭性3D细胞形态并增强黑色素瘤的生长
7. Somatic copy number amplification and hyperactivating somatic mutations of EZH2 correlate with DNA methylation and drive epigenetic silencing of genes involved in tumor suppression and immune responses in melanoma [O] . Tiffen, Jessamy, Wilson, Stephen, Gallagher, Stuart J., 2016

机译：EZH2的体细胞拷贝数扩增和过度激活的体细胞突变与DNA甲基化相关，并驱动黑色素瘤中涉及肿瘤抑制和免疫反应的基因的表观遗传沉默

Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations

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