Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study

Jimenez-Sousa Maria A.; Berenguer Juan; Fernandez-Rodriguez Amanda; Maria Medrano Luz; Aldamiz-Echevarria Teresa; Perez-Latorre Leire; Diez Cristina; Martin-Vicente Maria; Gutierrez-Rivas Monica; Martinez Isidoro; Resino Salvador

首页> 外文期刊>Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases >Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study

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Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study

机译：在6Q23区域中TNFAIP3上游的遗传变体与HIV / HCV-焦患者的肝病严重程度有关：横截面研究

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Background: TNFAIP3 is a crucial hepatoprotective factor due to its anti-inflammatory, anti-apoptotic, antioxidant and pro-regenerative functions. The aim of this study was to analyze the associations between genetic variants upstream of TNFAIP3 (rs675520, rs9376293 and rs6920220) and liver fibrosis severity and inflammation in HIV/HCV-coinfected patients.

机译：背景：TNFAIP3是由于其抗炎，抗凋亡，抗氧化剂和抗氧化剂和促腐蚀功能引起的至关重要的肝保护剂。本研究的目的是分析TNFAIP3上游遗传变异（RS675520，RS9376293和RS6920220）和肝纤维化严重程度和炎症在HIV / HCV-焦收感染患者中的关联。

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来源
《Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases》 |2019年第2019期|共9页
作者
Jimenez-Sousa Maria A.; Berenguer Juan; Fernandez-Rodriguez Amanda; Maria Medrano Luz; Aldamiz-Echevarria Teresa; Perez-Latorre Leire; Diez Cristina; Martin-Vicente Maria; Gutierrez-Rivas Monica; Martinez Isidoro; Resino Salvador;
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作者单位

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Hosp Gen Univ Gregorio Maranon Unidad Enfermedades Infecciosas VIH Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Hosp Gen Univ Gregorio Maranon Unidad Enfermedades Infecciosas VIH Madrid Spain;

Hosp Gen Univ Gregorio Maranon Unidad Enfermedades Infecciosas VIH Madrid Spain;

Hosp Gen Univ Gregorio Maranon Unidad Enfermedades Infecciosas VIH Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

Inst Salud Carlos III Unidad Infecc Viral &

Inmunidad Ctr Nacl Microbiol Madrid Spain;

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原文格式 PDF
正文语种 eng
中图分类预防医学、卫生学;
关键词
AIDS; Chronic hepatitis C; TNFAIP3; SNPs; Liver fibrosis; Inflammation;

机译：艾滋病;慢性丙型肝炎;tnfaip3;snps;肝纤维化;炎症;

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1. Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study [J] . Jimenez-Sousa Maria A., Berenguer Juan, Fernandez-Rodriguez Amanda, Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases . 2019,第期

机译：在6Q23区域中TNFAIP3上游的遗传变体与HIV / HCV-焦患者的肝病严重程度有关：横截面研究
2. Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study [J] . Mónica García-álvarez, Juan Berenguer, María A. Jiménez-Sousa, Scientific reports. . 2017,第1期

机译：MX1，OAS1和OAS2多态性与HIV / HCV-焦育患者的肝病的严重程度有关：横截面研究
3. Successful HCV Therapy Reduces Liver Disease Severity and Inflammation Biomarkers in HIV/HCV-Coinfected Patients With Advanced Cirrhosis: A Cohort Study [J] . Luz Maria Medrano, María Angeles Jiménez-Sousa, Salvador Resino, Frontiers in Medicine . 2021,第a期

机译：成功的HCV疗法可降低肝病严重程度和炎症生物标志物在HIV / HCV-焦化的先进肝硬化患者中：队列研究
4. Exploring database keyword search for association studies between genetic variants and diseases [C] . Dhawal Verma, Hesham H. Ali, Zhengxin Chen Conference on Information Technology and Quantitative Management . 2013

机译：探索数据库关键字搜索遗传变异和疾病之间的关联研究
5. Cross-sectional survey on disease severity in Japanese patients with harlequin ichthyosis/ichthyosis: Syndromic forms and quality-of-life analysis in a subgroup [D] . Murase Chiaki, 村瀬千晶 2019

机译：日本丑角鱼鳞病/鱼鳞病患者疾病严重程度的横断面调查：亚组的症状形式和生活质量分析
6. Mx1 OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study [O] . Mónica García-Álvarez, Juan Berenguer, María A. Jiménez-Sousa, -1

机译：一项横断面研究：Mx1OAS1和OAS2多态性与HIV / HCV合并感染患者的肝病严重程度有关
7. Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study [O] . Mónica García-Álvarez, Juan Berenguer, María A. Jiménez-Sousa, 2017

机译：MX1，OAS1和OAS2多态性与HIV / HCV-焦育患者的肝病的严重程度有关：横截面研究

Genetic variants upstream of TNFAIP3 in the 6q23 region are associated with liver disease severity in HIV/HCV-coinfected patients: A cross-sectional study

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