NEW AROMATIC ALCOHOL, BENZOYL GLYCOSIDIC ESTER AND ANTHRAQUINONE DERIVATIVE FROM THE AERIAL PARTS OF PHYLLANTHUS FRATERNUS WEBSTER

摘要

Phyllanthus fraternus Webster (Euphorbiaceae) is used in Indian traditional systems of medicine to treat diabetes, influenza, dyspepsia, indigestion, dysentery, jaundice, kidney stones, urinary tract diseases, vaginitis and skin eruptions. Phytochemical investigation of a methanolic extract of aerial parts of P. fraternus led to the isolation of a new aromatic alcohol characterized as 3'-methyl-3'-(3,4-dimethoxyphenyl)-1'-propanol (1), a benzoyl glycosidic ester identified as 2-n-dodecanoyl-salicyloyl-O-p-D-arabinopyranoside (2) and a new anthraquinone derivative 1-methoxy-2,4,8,9,10,11-hexahydroxy-3-methyl-6,13-anthracenedione (3) along with a known p-D-diglucoside (4). The structures of isolated phytoconstituents were established on the basis of 1D and 2D NMR, FT-IR, UV and MS data.