Spot PC ratio estimates of 24-hour proteinuria are more unreliable in lupus nephritis than in other forms of chronic glomerular disease

摘要

Spot urine protein/creatinine ratio (PCR) is often used clinically to estimate 24-hour (24-h) proteinuria. However, urine PCR shows considerable hour to hour variability. In lupus nephritis (LN), spot PCR reveals this variability, while longer timed collections conceal it. Spot PCR performs well in cohort studies, where its variability is mitigated by averaging the data. However, spot PCR variability becomes a liability for individual patient management. This work is the first to compare spot PCR variability in LN and chronic kidney disease (CKD).