Iron-Promoted Domino Dehydrogenative Annulation of Deoxybenzoins and Alkynes Leading to beta-Aryl-alpha-Naphthols

摘要

A strategy for synthesis of beta-aryl-alpha-naphthols has been established through an iron-promoted domino C(sp(3))-H/C(sp)-H and C(sp(2))-H/C(sp)-H dehydrogenative coupling of deoxybenzoins and alkynes. The synthesis uses inexpensive materials with a broad substrate scope and features simple operations with excellent regioselectivity. This study provides an alternative access to various beta-aryl-alpha-naphthols and the synthetic protocol should have potential applications in medicinal, materials science, and related areas.