Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

Cui Li‐li; Golubczyk Dominika; Tolppanen Anna‐Maija; Boltze Johannes; Jolkkonen Jukka

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Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

机译：缺血性中风的细胞疗法：是临床前和临床研究设计的差异，负责翻译效果的翻译丧失吗？

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来源
《Annals of neurology》 |2019年第1期|共12页
作者
Cui Li‐li; Golubczyk Dominika; Tolppanen Anna‐Maija; Boltze Johannes; Jolkkonen Jukka;
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作者单位

Department of NeurologyXuanwu Hospital of Capital Medical UniversityBeijing China;

Department of NeurosurgerySchool of Medicine Collegium Medicum University of Warmia and;

School of PharmacyUniversity of Eastern FinlandKuopio Finland;

School of Life SciencesUniversity of WarwickCoventry United Kingdom;

Institute of Clinical Medicine‐NeurologyUniversity of Eastern FinlandKuopio Finland;

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原文格式 PDF
正文语种 eng
中图分类神经病学;
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1. Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy? [J] . Cui Li‐li, Golubczyk Dominika, Tolppanen Anna‐Maija, Annals of neurology . 2019,第1期

机译：缺血性中风的细胞疗法：是临床前和临床研究设计的差异，负责翻译效果的翻译丧失吗？
2. A 2?×?2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model [J] . Md Nasrul Hoda, Susan C Fagan, Mohammad B Khan, Experimental & translational stroke medicine . 2014,第3期

机译：2？×？2因子设计用于米诺环素和远程缺血性适应症的联合治疗：在小鼠血栓栓塞性中风模型的临床前试验中的功效
3. Cell Therapy for Ischemic Stroke: How to Turn a Promising Preclinical Research into a Successful Clinical Story [J] . Mangin Gabrielle, Kubis Nathalie Stem cell reviews and Reports . 2019,第2期

机译：用于缺血性卒中的细胞疗法：如何将一个有前途的临床前研究变成一个成功的临床故事
4. Transcranial near infrared laser therapy (NILT) to treat acute ischemic stroke: a review of efficacy, safety and possible mechanism of action derived from rabbit embolic stroke studies [C] . Paul A. Lapchak, Jackson Streeter, Luis De Taboada Mechanisms for low-light therapy V . 2010

机译：经颅近红外激光治疗急性缺血性中风：兔栓塞性中风研究的疗效，安全性和可能的作用机制综述
5. Stimulating the Facial Nerve to Treat Ischemic Stroke: A Systematic Review of Preclinical and Clinical Studies [D] . ?Robeny, Justin 2020

机译：刺激面神经治疗缺血性中风：临床前和临床研究的系统评价
6. A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model [O] . Md Nasrul Hoda, Susan C Fagan, Mohammad B Khan, 2014

机译：米诺环素和远距缺血性适应症联合治疗的2××2析因设计：在小鼠血栓栓塞性中风模型的临床前试验中的功效
7. Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy? [O] . Li‐li Cui, Dominika Golubczyk, Anna‐Maija Tolppanen, 2019

机译：缺血性中风的细胞疗法：是临床前和临床研究设计的差异，负责翻译效果的翻译丧失吗？

Cell therapy for ischemic stroke: Are differences in preclinical and clinical study design responsible for the translational loss of efficacy?

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