3D Personalized Monte Carlo Dosimetry in Y-90 Microsphere Radioembolization

摘要

Introduction: GEANT4 application for tomographic emission (GATE) is an open source Monte Carlo (MC) software allowing for the in-silico simulation of theranostic scenarios dedicated to imaging and therapeutic applications such as image-based dosimetry. Compared with organ-based dosimetry, three-dimensional (3D) and patient-specific dosimetry better accounts for radionuclide distribution and anatomic patient variability. The purpose of the study is to develop a workflow for radiation dose prediction of Y-90 microsphere selective internal radiotherapy (Y-90 SIRT) of liver tumor.