Therapeutic Monitoring of Carbamazepine in Epilepsy Patients by Highly Sensitive LC/MS Method and its Clinical Applications

摘要

Background: Carbamazepine (CBZ) has complex pharmacokinetic properties leading to fluctuation in plasma level, which requires routine therapeutic drug monitoring (TDM) to ensure its efficacy and prevent adverse effects. The objective of this study is directed towards developing and validating a simple, precise, rapid and highly sensitive liquid chromatography-mass spectrometry (LC/MS) technique for measuring CBZ concentration in human plasma of epileptic patients in routine TDM.