Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

Laura M. Bohn; Jeffrey Aubé

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Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

机译：寻求（和发现）kappa阿片受体的偏见配体

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src="http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amclct/2017/amclct.2017.8.issue-7/acsmedchemlett.7b00224/20170707/images/medium/ml-2017-00224v_0006.gif">The discovery and characterization of two classes of kappa opioid receptor agonists that are biased for G protein over βarrestin signaling are described.

机译：src =“http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/amclct/2017/amclct.2017.8.issue-7/acsmedchemlett.7b00224/20170707070707070707070707070707/images/medium/ml 描述了关于在βArrestin信号传导上偏向G蛋白的两类Kappa阿片受体激动剂的发现和表征的发现和表征。

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《ACS medicinal chemistry letters》 |2017年第7期|共7页
作者
Laura M. Bohn; Jeffrey Aubé;
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作者单位

Departments of Molecular Medicine and Neuroscience The Scripps Research Institute Jupiter Florida 33458 United States;

Division of Chemical Biology and Medicinal Chemistry UNC Eshelman School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill North Carolina 27599 United States;

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原文格式 PDF
正文语种 eng
中图分类药学;化学;
关键词
biased ligands; functional selectivity; G protein-coupled receptors; kappa opioid receptor agonists; βArrestin;

机译：偏向配体;功能选择性;G蛋白偶联受体;κ阿片类受体激动剂;βArrestin;

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1. Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor [J] . Laura M. Bohn, Jeffrey Aubé ACS medicinal chemistry letters . 2017,第7期

机译：寻求（和发现）kappa阿片受体的偏见配体
2. Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neuronss [J] . Jamshidi Raehannah J., Sullivan Laura C., Jacobs Blaine A., The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2016,第2期

机译：偏向配体Norbinaltorphimine长期降低Kappa阿片受体功能，需要c-Jun N末端激酶活性和周围感觉神经元的新蛋白合成。
3. Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neuronss [J] . Jamshidi Raehannah J., Sullivan Laura C., Jacobs Blaine A., The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2016,第2期

机译：通过偏置配体，NorbinalTorphimine的Kappa阿片受体功能的长期降低需要C-Jun N-末端激酶活性和外周感觉神经元的新蛋白质合成
4. Opioid Ligand Binding to Opioid Receptors: Insight and Implications for Peptide Design [C] . Michael J. Ferracane, Jane V. Aldrich American Peptide Symposium . 2015

机译：阿片类配体与阿片受体的结合：肽设计的见解和影响
5. Design and Synthesis of Functionally Selective Kappa Opioid Receptor Ligands [D] . Johnson, Stephanie Nicole. 2017

机译：功能选择性κ阿片受体配体的设计与合成
6. Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand Norbinaltorphimine Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons [O] . Raehannah J. Jamshidi, Laura C. Sullivan, Blaine A. Jacobs, -1

机译：偏向配体Norbinaltorphimine长期降低Kappa阿片受体功能需要c-Jun N末端激酶活性和周围感觉神经元的新蛋白合成。
7. Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor [O] . Laura M. Bohn, Jeffrey Aubé 2017

机译：寻求（并发现）kappa阿片受体的偏见配体

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor

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