Comparative Assessment of Spray Drying and Hot Melt Extrusion as Amorphous Solid Dispersion Manufacturing Processes

摘要

Part I provided an overview of the historical perspective of the genesis and application of spray drying and melt extrusion as robust and efficient manufacturing processes1. In this section, an attempt will be made to compare and contrast spray drying and melt extrusion amorphous solid dispersion manufacturing processes by focusing on three key components - feed material preparation, processing conditions and product characteristics.