Development of an In-House Cell Free Extract Process and Robotic Platform for Expression Optimization

摘要

Stratified medicine and personalized therapeutics offer a route to more efficacious patient treatment regimens. However, the diversity of therapeutics required, and the small market size for each, requires a more agile manufacturing method than those currently in use to ensure these products are readily available and affordable. Cell Free Expression (CFE), a method which utilizes biological components extracted from living cells to produce recombinant proteins, could be the solution to this manufacturing challenge.