Water Proton NMR for Noninvasive Chemical Analysis and Drug Product Inspection

摘要

In a typical pharmaceutical solution, water is 103 - 106 more concentrated than the API, which is fully surrounded by water molecules. This provides an opportunity to use spectroscopic signals from water to assess the quality of pharmaceutical solutions. In this article, examples of using the water proton NMR signal for chemical analysis are presented. Water proton NMR can be conducted noninvasively (without opening the vial) using inexpensive benchtop time-domain NMR spectrometers. The measurement is very simple and fast. This feature makes it possible to collect quantitative data on every vial of a drug product in its entire lifecycle, from point-of-release to point-of-care.