SCY-078, a novel IV/oral triterpenoid anti-fungal treatment in development for vulvovaginal candidiasis and other severe invasive fungal infections, is not embryo/feto-toxic

Carruthers C.; Barat S.; Thomas P.; Lewis E.

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SCY-078, a novel IV/oral triterpenoid anti-fungal treatment in development for vulvovaginal candidiasis and other severe invasive fungal infections, is not embryo/feto-toxic

机译：SCY-078，一种新型IV /口服三萜类抗真菌治疗在外阴阴道念珠菌病和其他严重的侵袭性真菌感染，不是胚胎/胎毒性

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来源
《American Journal of Obstetrics and Gynecology》 |2018年第6期|共3页
作者
Carruthers C.; Barat S.; Thomas P.; Lewis E.;
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作者单位

SCYNEXIS Inc Jersey City NJ USA;

SCYNEXIS Inc Jersey City NJ USA;

Charles River Labs Wilmington MA USA;

Charles River Labs Wilmington MA USA;

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原文格式 PDF
正文语种 eng
中图分类妇产科学;
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1. SCY-078, a novel IV/oral triterpenoid anti-fungal treatment in development for vulvovaginal candidiasis and other severe invasive fungal infections, is not embryo/feto-toxic [J] . Carruthers C., Barat S., Thomas P., American Journal of Obstetrics and Gynecology . 2018,第6期

机译：SCY-078，一种新型IV /口服三萜类抗真菌治疗在外阴阴道念珠菌病和其他严重的侵袭性真菌感染，不是胚胎/胎毒性
2. A multicenter, randomized, evaluator blinded, active-controlled study to evaluate the safety and efficacy of oral SCY-078 vs. oral fluconazole in 96 subjects with moderate to severe vulvovaginal candidiasis [J] . Helou S., Angulo D. American Journal of Obstetrics and Gynecology . 2017,第6期

机译：多中心，随机，评估仪的盲，主动对照研究，以评估口服SCY-078对76名受试者中的口服SCY-078对抗的安全性和疗效，中度至严重的漏洞念珠菌病
3. In vitro activity of ibrexafungerp (formerly SCY-078) against Candida spp. (including fluconazole-resistant isolates) in development for the treatment of vulvovaginal candidiasis [J] . Borroto-Esoda K., Barat S., Angulo D. American Journal of Obstetrics and Gynecology . 2019,第6期

机译：对念珠菌SPP的伊布拉德吞噬器（前身SCY-078）的体外活性。（包括抗氟康唑抗性分离物）用于治疗外阴阴道念珠菌病
4. Development of Vaccines for Invasive Fungal Infections [D] . Rayens, Emily. 2021

机译：侵袭性真菌感染疫苗的开发
5. Pharmacodynamic Target Evaluation of a Novel Oral Glucan Synthase Inhibitor SCY-078 (MK-3118) Using an In Vivo Murine Invasive Candidiasis Model [O] . Alexander J. Lepak, Karen Marchillo, David R. Andes 2015

机译：使用体内小鼠侵袭性念珠菌病模型的新型口服葡聚糖合酶抑制剂SCY-078（MK-3118）的药效学目标评估。
6. Oral versus intra-vaginal imidazole and triazole anti-fungal agents for the treatment of uncomplicated vulvovaginal candidiasis (thrush):a systematic review [O] . Watson Margaret C, Grimshaw Jeremy M, Bond Christine M, 2002

机译：口服与阴道内咪唑和三唑类抗真菌药治疗单纯性念珠菌性阴道念珠菌病（鹅口疮）：系统评价

SCY-078, a novel IV/oral triterpenoid anti-fungal treatment in development for vulvovaginal candidiasis and other severe invasive fungal infections, is not embryo/feto-toxic

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