Synthesis and characterization of hybrid Anderson hexamolybdoaluminates(III) functionalized with indometacin or cinnamic acid

摘要

The single‐side Al‐centred tris‐functionalized hybrid organic–inorganic Anderson polyoxomolybdates (C 16 H 36 N) 3 [Al(OH) 3 Mo 6 O 18 (OCH 2 ) 3 CNH(C 10 H 8 O)]·C 9 H 7 N·4CH 3 OH·5H 2 O ( AlMo 6 ‐NH‐Cin ; Cin is cinnamic acid, C 10 H 9 O 2 ) and (C 16 H 36 N) 3 [Al(OH) 3 Mo 6 O 18 (OCH 2 ) 3 CNH(C 19 H 15 ClNO 3 )]·9H 2 O ( AlMo 6 ‐NH‐Indo ; Indo is indometacin, C 19 H 16 ClNO 4 ) have been prepared in a mild three‐step synthesis and structurally characterized by single‐crystal X‐ray diffraction, 1 H NMR and IR spectroscopies and elemental analysis. Both AlMo 6 ‐NH‐Cin and AlMo 6 ‐NH‐Indo crystallize in the orthorhombic space group Pbca . The antibacterial activities of AlMo 6 ‐NH‐Cin and AlMo 6 ‐NH‐Indo against the Gram‐negative human mucosal pathogen Moraxella catarrhalis were investigated by determination of the minimum inhibitory concentration, which is 32?μg?ml ?1 for AlMo 6 ‐NH‐Cin and 256?μg?ml ?1 for AlMo 6 ‐NH‐Indo .