Perioperative Bevacizumab-based Triplet Chemotherapy in Patients With Potentially Resectable Colorectal Cancer Liver Metastases

Pietrantonio Filippo; Cotsoglou Christian; Fuca Giovanni; Lo Vullo Salvatore; Nichetti Federico; Milione Massimo; Coppa Jorgelina; Vaiani Marta; Alessi Alessandra; Prisciandaro Michele; Busset Michele Droz-Dit; Morano Federica; Corallo Salvatore; Lazzati Silvia; Antista Maria; Mennitto Alessia; Randon Giovanni; Raimondi Alessandra; Belfiore Antonino; Padovano Barbara; Perrone Federica; Mariani Luigi; Di Bartolomeo Maria; de Braud Filippo; Mazzaferro Vincenzo

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Perioperative Bevacizumab-based Triplet Chemotherapy in Patients With Potentially Resectable Colorectal Cancer Liver Metastases

机译：基于围手术期贝伐单抗的三重态化疗，患者患者潜在的可转型结直肠癌肝转移酶

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Neoadjuvant triplet chemotherapy plus bevacizumab achieved pathologic response in 63% of colorectal cancer liver metastases. Early tumor shrinkage and posttreatment positron emission tomography predicted pathologic findings.

机译：Neoadjuvant Triplet化疗加贝伐单抗在63％的结肠直肠癌肝转放酶中实现了病理反应。早期肿瘤收缩和后病态正电子发射断层扫描预测病理结果。

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《Clinical colorectal cancer》 |2019年第1期|共16页
作者
Pietrantonio Filippo; Cotsoglou Christian; Fuca Giovanni; Lo Vullo Salvatore; Nichetti Federico; Milione Massimo; Coppa Jorgelina; Vaiani Marta; Alessi Alessandra; Prisciandaro Michele; Busset Michele Droz-Dit; Morano Federica; Corallo Salvatore; Lazzati Silvia; Antista Maria; Mennitto Alessia; Randon Giovanni; Raimondi Alessandra; Belfiore Antonino; Padovano Barbara; Perrone Federica; Mariani Luigi; Di Bartolomeo Maria; de Braud Filippo; Mazzaferro Vincenzo;
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作者单位

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Gen Surg &

Liver Transplantat Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Clin Epidemiol &

Trial Org Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Pathol &

Lab Med Milan Italy;

Fdn IRCCS Ist Nazl Tumori Gen Surg &

Liver Transplantat Milan Italy;

Fdn IRCCS Ist Nazl Tumori Radiol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Nucl Med Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Gen Surg &

Liver Transplantat Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Pathol &

Lab Med Milan Italy;

Fdn IRCCS Ist Nazl Tumori Nucl Med Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Dept Pathol &

Lab Med Milan Italy;

Fdn IRCCS Ist Nazl Tumori Clin Epidemiol &

Trial Org Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Fdn IRCCS Ist Nazl Tumori Med Oncol Dept Milan Italy;

Univ Milan Oncol &

Hemato Oncol Dept Milan Italy;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Colorectal cancer liver metastases; FGD-PET/CT; Pathologic response; Triplet chemotherapy; Tumor regression grade;

机译：结肠直肠癌肝转移;FDG-PET / CT;病理反应;三重态化疗;肿瘤回归等级;

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专利

1. Perioperative Bevacizumab-based Triplet Chemotherapy in Patients With Potentially Resectable Colorectal Cancer Liver Metastases [J] . Pietrantonio Filippo, Cotsoglou Christian, Fuca Giovanni, Clinical colorectal cancer . 2019,第1期

机译：基于围手术期贝伐单抗的三重态化疗，患者患者潜在的可转型结直肠癌肝转移酶
2. Timing of Perioperative Chemotherapy Does Not Influence Long-Term Outcome of Patients Undergoing Combined Laparoscopic Colorectal and Liver Resection in Selected Upfront Resectable Synchronous Liver Metastases [J] . Ratti Francesca, Fuks David, Cipriani Federica, World Journal of Surgery: Official Journal of the Societe Internationale de Chirurgie, Collegium Internationale Chirurgiae Digestivae, and of the International Association of Endocrine Surgeons . 2019,第12期

机译：围手术期化疗的时序不会影响所选腹腔镜结直肠癌和肝切除组合的患者的长期结果，在选定的前期可转移同步肝转放酶中
3. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. [J] . Nordlinger B, Sorbye H, Glimelius B The Lancet . 2008,第9617期

机译：围手术期用FOLFOX4进行的化疗以及单独手术与单独手术治疗可切除的结直肠癌肝转移（EORTC组间试验40983）：一项随机对照试验。
4. High-Depth Sequencing of Over 750 Genes Supports Linear Progression of Primary Tumors and Metastases in the Majority of Patients with Liver-Limited Metastatic Colorectal Cancer [C] . Simeen Malik, Iain Beehuat Tan, Kalpana Ramnarayanan, International Molecular Medicine Tri-Conference. . 2015

机译：超过750个基因的高深度测序支持肝脏有限转移性结直肠癌大多数患者的原发性肿瘤和转移的线性进展
5. Cost-effectiveness of imaging and surgery in patients with colorectal cancer liver metastases. [D] . Gazelle, Guy Scott. 1999

机译：大肠癌肝转移患者影像和手术的成本效益。
6. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial [O] . Bernard Nordlinger, Halfdan Sorbye, Bengt Glimelius, -1

机译：围手术期用FOLFOX4化疗以及单独手术与手术对结直肠癌可切除肝转移的疗效（EORTC组间试验40983）：一项随机对照试验
7. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial [O] . B. Nordlinger, H. Sorbye, B. Glimelius, 2008

机译：FOLFOX4围手术期化疗和手术与单独手术治疗癌症结直肠癌可切除的肝转移（EORTC Intergroup trial 40983）：随机对照试验

Perioperative Bevacizumab-based Triplet Chemotherapy in Patients With Potentially Resectable Colorectal Cancer Liver Metastases

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