Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically III Children with Normal and Augmented Renal Clearance

摘要

Background Critically ill children frequently display observed alterations of pharmacokinetic (PK) parameters, leading to a reduction in beta-lactam concentrations. This study aimed to develop a PK population model for piperacillin in order to optimize individual dosing regimens.