2D Nanostructured Metal Hydroxides with Gene Delivery and Theranostic Functions; A Comprehensive Review

Choi Goeun; Eom Sairan; Vinu Ajayan; Choy Jin‐Ho

摘要

Abstract > Layered double hydroxides (LDHs) with two dimensional structure have been attracted considerable interest in exploring new intercalative nanohybrids, such as inorganic‐LDHs, organic‐LDHs and bio‐LDHs ones, which often exhibit extraordinarily synergetic effects and complementary performances. More recently, bio‐related nanotechnology becomes one of the most essential research field in the viewpoint of the health and safety of human being. In this regard, LDHs have been focused as an important inorganic material for gene and drug delivery carriers with imaging and targeting functions. In the present review, an attempt has been made to describe gene delivery systems based on LDH nanoparticles in terms of synthetic routes of gene‐LDH nanohybrids, their physico‐chemical properties, intercellular uptake mechanisms, intracellular trafficking pathways and drug resistance, and passive and active targeting functions in in‐vitro and in‐vivo , and finally imaging functions. And recent studies of gene‐therapies with LDHs are also discussed from the viewpoint of state‐of‐the‐art nanohybrids technology. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>抽象</ title> >分层双氢氧化物（LDH）具有二维结构的二维结构已经吸引了相当大的兴趣探索新的互连纳米嗜含量，例如无机-LDHS，有机LDH和BIO-LDHS，它们通常表现出非常有价值的效果和互补性性能。最近，生物相关纳米技术在人类健康和安全的观点中成为最重要的研究领域之一。在这方面，LDHS已被聚焦为具有成像和靶向功能的基因和药物输送载体的重要无机材料。在本综述中，已经尝试描述基于LDH纳米颗粒的基因纳米颗粒的基因递送系统，其基因-LDH纳米胺的合成途径，它们的物理化学性质，细胞间吸收机制，细胞内运输途径和耐药性和被动和被动和在体外的活性靶向功能在 - 体外</ i>中的vivo </ i>，以及最终成像功能。并从最先进的纳米冬次技术的观点出发，还讨论了与LDHs的基因治疗的研究。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-16132/'>《Chemical record》</a> <b style="margin: 0 2px;">|</b><span>2018年第8期</span><b style="margin: 0 2px;">|</b><span>共21页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Choi Goeun&option=202" target="_blank" rel="nofollow">Choi Goeun;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Eom Sairan&option=202" target="_blank" rel="nofollow">Eom Sairan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vinu Ajayan&option=202" target="_blank" rel="nofollow">Vinu Ajayan;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Choy Jin‐Ho&option=202" target="_blank" rel="nofollow">Choy Jin‐Ho;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Center for Intelligent Nano-Bio Materials (CINBM) Department of Chemistry and Nano ScienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> <p>Center for Intelligent Nano-Bio Materials (CINBM) Department of Chemistry and Nano ScienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> <p>Global Innovative Center for Advanced Nanomaterials Faculty of Engineering and Natural Built Environment The University of NewcastleUniversity DriveCallaghan NSW 2308 Australia;</p> <p>Center for Intelligent Nano-Bio Materials (CINBM) Department of Chemistry and Nano ScienceEwha Womans UniversitySeoul 03760 Republic of Korea;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/159.html" title="化学">化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=layered double hydroxide&option=203" rel="nofollow">layered double hydroxide;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=inorganic nanovehicle&option=203" rel="nofollow">inorganic nanovehicle;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=gene delivery&option=203" rel="nofollow">gene delivery;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intracellular trafficking pathway&option=203" rel="nofollow">intracellular trafficking pathway;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=cellular delivery&option=203" rel="nofollow">cellular delivery;</a> </p> <div class="translation"> 机译：层状双氢氧化物;无机纳米伏特氏;基因递送;细胞内贩运途径;细胞递送; 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including the metal oxide nanostructures doped with a heterogeneous element</a> <b>[P]</b> . <span> 外国专利：  KR20210048055A </span> <span> . 2021-05-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用微波等离子体器件掺杂有异质元件的金属氧化物纳米结构的方法，金属氧化物纳米结构掺杂使用相同的异质元件，并且光催化剂包括掺杂有异质元件的金属氧化物纳米结构 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130501093458.html">Method for producing metal oxide nanostructures doped with a heterogeneous element using microwave plasma device the metal oxide nanostructures doped with the heterogeneous element manufactured using the same and photocatalysts including the metal oxide nanostructures doped with a heterogeneous element</a> <b>[P]</b> . <span> 外国专利：  KR102326833B1 </span> <span> . 2021-11-17</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用微波等离子体器件掺杂有非均相元件的金属氧化物纳米结构的方法使用相同和光催化剂制造的金属氧化物纳米结构，所述金属氧化物纳米结构包括使用相同和光催化剂制成的包括金属氧化物纳米结构掺杂有异质元件 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130501074075.html">METHOD FOR PRODUCING NANOSTRUCTURED DOUBLE HYDROXIDES BASED ON ALUMINIUM AND ALKALINE EARTH METALS SUCH AS MAGNESIUM OR CALCIUM, EXHIBITING THE PROPERTY OF INCREASING THE pH OF A CELLULAR MEDIUM, AND NANOSTRUCTURES PRODUCED THEREBY</a> <b>[P]</b> . <span> 外国专利：  RU2758671C1 </span> <span> . 2021-11-01</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：基于铝和碱土金属如镁或钙的纳米结构双氢氧化物制备纳米结构的方法，表现出增加细胞培养基的pH的性质和由此产生的纳米结构 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul 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