Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines

摘要

The synthesis of quinolines has been achieved through a one-pot, two-step tandem reaction catalyzed with Ag-Pd alloy nanoparticles supported on carbon. Ag-Pd alloy nanoparticles catalyzed the coupling of a ketone with a primary alcohol through a hydrogen autotransfer process, which yields alpha-alkylated ketones under an Ar flow. These are reacted with 2-aminobenzyl alcohols in a modified Friedlander synthesis to give polysubstituted quinolines in moderate to good yields.