GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice

摘要

Heatstroke is still a potentially fatal threat during summer heat waves, despite improved prevention and treatment. It is reported that the transient receptor potential vanilloid 4 (TRPV4) inhibitoi may protect septicemia mice. Many aspects ot heatstroke have been defined, from the sepsis-mimic inflammatory response to hxperthermia Hence, TRPV4 may be a therapeutic target for heatstroke. The results in murine models of heatstroke verified that GSK2193874 as a selected TRPV4 inhibitor, was injected at heatstroke onset, and then reduced the reduction of core temperature the death rate, wet/dry ratio of the lung, levels of tumor necrosis factor-alpha (TNTF-alpha) and mterleukin (IL)-6, coagulation indicators, the degree of organ injury, and caspase-3/7 activity (P 0.05). But GSK2193874 treatment before heat stress did not improve the svmptoms of heatstroke mice. Therefore TRPV4 should be involved in heatstroke-induced injury. Timely GSK2193874 admmistiation may be useiul to reduce heatstroke-induced injury. TRPV4 may be a potential new therapeutic target in fatal heatstroke.