A sliding scale: the many faces of Ctf7/Eco1 cohesion establishment factor in DNA repair.

摘要

A baker desired to open a second factory from which to prepare her wares. The issue of course was the revered but single recipe book. She painstakingly reproduced each page and, for safekeeping, clipped together each original and page-copy pair. When the process was complete, each pair was undipped and then separated to form two recipe books. So it is with chromosomes-the revered instructions of life. Each chromosome is faithfully replicated during S phase to produce two identical sister chromatids which are later segregated during mitosis into the newly-forming daughter cells. To identify chromatids as sisters between S phase and mitosis, replication products are "clipped" together (Fig. 1).