Organized folding of chromatin in the 3-dimensional space of the nucleus and its localized association with nuclear structural elements is known to influence gene-expression. Non-random positioning of chromosomes within the nucleus results in zones, termed chromosome territories, that harbor specific chromosomal sequences in a fixed geographical region that are juxtaposed with similarly specified neighboring territories.1 Locations of chromosome territories are mostly invariant, but specific chromosome segments can move to engage in intra-chromosomal or inter-chromosomal interactions.
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