Microwave-assisted copper(I) catalyzed A(3)-coupling reaction: Reactivity, substrate scope and the structural characterization of two coupling products

摘要

The application of highly efficient catalyst [{Cu(mu - I)(2)Cu}(PPh3)(4)] for the synthesis of biologically and pharmaceutically important propargylamine derivatives through microwave assisted A(3)-coupling reaction is described. The A(3)-coupling reaction performed under microwave conditions with a catalyst loading of 0.1 mol% produced propargylamines in almost quantitative isolated yields. Most of the reactions were completed within 5 min. Various alkynes, amines and aldehydes were employed to produce propargylamines in excellent yields.