Von ?Fehlanpassungen‘ und ?metabolischen Ghettos‘: Zur Konzeptualisierung globaler Gesundheitsunterschiede im Feld der Developmental Origins of Health and Disease         xmlns='http://www.wiley.com/namespaces/wiley' href='#bewi201801902-note-1001'/>

Penkler Michael; Müller Ruth

摘要

Abstract > On ‘Mismatch’ and ‘Metabolic Ghettos:’ The Conceptualization of Global Health Differences in Research on the Developmental Origins of Health and Disease . Epigenetic approaches to human health have received growing attention in the past two decades. They allow to view the development of human organisms as plastic, i.e. as open to influences from the social and material environment such as nutrition, stress, and trauma. This has lent new credence to approaches in biomedicine that aim to draw attention to the importance of development for later life health. Some scholars in the social sciences and humanities have welcomed such approaches as a departure from gene‐centric perspectives and as an opportunity for highlighting the social and political determinants of health and illness. Others have warned that they might lead to new forms of biological reductionisms and determinisms. In this article, we explore how research on developmental plasticity addresses and articulates global health disparities, specifically in the context of postcolonial India. We discuss two prominent approaches from the field of Developmental Origins of Health and Disease (DOHaD) that build on epigenetic perspectives on health and illness and view different global rates of disease susceptibility as the result of developmental processes: first, the ‘mismatch paradigm’ by Peter Gluckman and Mark Hanson and second, the ‘metabolic ghetto’ concept by Jonathan Wells. We highlight how both approaches render historical and social factors meaningful for the development of global health disparities, but emphasize how they at the same time remain prone to determinisms and reductionisms reminiscent of a gene‐centric perspective. DOHaD actors themselves are critical of these tendencies, and in conclusion we explore novel opportunities for interdisciplinary collaborations enabled by this critical potential. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“de”> <标题类型=“main”>抽象</ title> > “不匹配”和“代谢贫民区：”健康疾病发展起源研究的全球健康差异的概念化</ b> 。在过去的二十年中，人类健康的表观遗传方法受到了不断的关注。他们允许观察人体生物的发展作为塑料，即营养，压力和创伤等社会和物质环境的影响。这在生物医学的途径借出了新的信任，旨在提请对后期生命健康发展的重要性。社会科学和人文学科的一些学者欢迎这些方法作为从基因为中心的观点出发，并作为突出健康和疾病的社会和政治决定因素的机会。其他人警告说，他们可能会导致新形式的生物修改主义和决定措施。在本文中，我们探讨了发展塑性地址的研究如何，明确地在后殖民印度的背景下阐明了全球卫生差异。我们讨论了从健康和疾病的发育起源领域（Dohad）领域的两个突出方法，这些方法是对健康和疾病的表观遗传观点，并视为发展过程结果的不同全球疾病易感性：首先，“不匹配范式” Peter Gluckman和Mark Hanson和第二，Jonathan Wells的“代谢贫民窟”的概念。我们强调两种方法如何使有意义的历史和社会因素对全球卫生障碍的发展有意义，但强调他们的同时如何持续确定主义和减少主义让人让人想起一种以基因为中心的观点。 Dohad Actors本身对这些趋势至关重要，总之，我们探索了这种关键潜力所支持的跨学科合作的新机遇。 </ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15750/'>《Berichte zur Wissenschaftsgeschichte》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共21页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Penkler Michael&option=202" target="_blank" rel="nofollow">Penkler Michael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Müller Ruth&option=202" target="_blank" rel="nofollow">Müller Ruth;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Munich Center for Technology in SocietyTechnische Universit?t MünchenArcisstra?e 21 D- 80333 München;</p> <p>Munich Center for Technology in SocietyTechnische Universit?t MünchenArcisstra?e 21 D- 80333 München;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/144.html" title="自然科学现状及发展">自然科学现状及发展;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Developmental Origins of Health and Disease&option=203" rel="nofollow">Developmental Origins of Health and Disease;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epigenetics&option=203" rel="nofollow">epigenetics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=plasticity&option=203" rel="nofollow">plasticity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=global health disparities&option=203" rel="nofollow">global health disparities;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=postcolonialism&option=203" rel="nofollow">postcolonialism;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mismatch&option=203" rel="nofollow">mismatch;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=metabolic ghetto&option=203" rel="nofollow">metabolic ghetto;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=genetics&option=203" rel="nofollow">genetics;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=epigenetic determinism&option=203" rel="nofollow">epigenetic determinism;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=interdisciplinary collaborations&option=203" rel="nofollow">interdisciplinary collaborations;</a> </p> <div class="translation"> 机译：健康和疾病的发育起源;表观生物;可塑性;全球卫生差异;后殖民主义;不匹配;代谢贫民区;遗传学;表观遗传决定症;跨学科合作;跨学科的合作; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div 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