A standardized ZAP-70 assay - Lessons learned in the trenches

摘要

Background: The disease of chronic lymphocytic leukemia (CLL) has been shown to exhibit varying clinical outcomes based an reported laboratory parameters. One of these parameters involves the measurement of the protein levels of zeta-associated protein (ZAP-70) in CLL cells. A standardized assay has not yet reached consensus in the clinical cytometry community.