Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients

Lioger Bertrand; Edupuganti Soujanya Ratna; Mulleman Denis; Passot Christophe; Desvignes Celine; Bejan-Angoulvant Theodora; Thibault Gilles; Gouilleux-Gruart Valerie; Melet Julien; Paintaud Gilles; Ternant David

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Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients

机译：抗原负担和血清IgG浓度影响风湿性关节炎患者的Rituximab药代动力学

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AimsRituximab is a monoclonal antibody directed against CD20, which is approved in rheumatoid arthritis (RA). This study aimed at assessing the influence of CD19+ cell counts as target-antigen amount, and of immunoglobulin G (IgG) serum concentrations on rituximab pharmacokinetics in RA patients.

机译：Aimsrituximab是针对CD20的单克隆抗体，其在类风湿性关节炎（RA）中被批准。该研究旨在评估CD19 +细胞计数作为靶抗原量的影响，以及RA患者中Rituximab药代动力学的免疫球蛋白G（IgG）血清浓度。

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来源
《British Journal of Clinical Pharmacology》 |2017年第8期|共9页
作者
Lioger Bertrand; Edupuganti Soujanya Ratna; Mulleman Denis; Passot Christophe; Desvignes Celine; Bejan-Angoulvant Theodora; Thibault Gilles; Gouilleux-Gruart Valerie; Melet Julien; Paintaud Gilles; Ternant David;
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作者单位

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

Univ Francois Rabelais Tours CNRS GICC UMR 7292 Tours France;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
elimination rate constant; immunoglobulin; pharmacokinetics; rheumatoid arthritis; rituximab;

机译：消除速率常数;免疫球蛋白;药代动力学;类风湿性关节炎;利妥昔单抗;

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专利

1. Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients [J] . Bertrand Lioger, Soujanya Ratna Edupuganti, Denis Mulleman, British journal of clinical pharmacology . 2017,第8期

机译：类风湿关节炎患者的抗原负担和血清IgG浓度影响利妥昔单抗的药代动力学
2. Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients [J] . Lioger Bertrand, Edupuganti Soujanya Ratna, Mulleman Denis, British Journal of Clinical Pharmacology . 2017,第8期

机译：抗原负担和血清IgG浓度影响风湿性关节炎患者的Rituximab药代动力学
3. Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients [J] . Lioger Bertrand, Edupuganti Soujanya Ratna, Mulleman Denis, British Journal of Clinical Pharmacology . 2017,第8期

机译：抗原负担和血清IgG浓度影响风湿性关节炎患者的Rituximab药代动力学
4. Changes in the Glycosylation Pattern of Total Serum IgG in Patients with Rheumatoid Arthritis analyzed by MALDI-TOF MS [C] . Katrin Sparbier, Hassan Dihazi, Sabine Blaschke, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：MARDI-TOF MS分析类风湿性关节炎患者总血清IgG的糖基化模式的变化
5. The relationship between red blood cell concentration and inflammation: Studies in runners and rheumatoid arthritis patients [D] . Hamilton, Cynthia Louise 1997

机译：红细胞浓度与炎症之间的关系：跑步者和类风湿关节炎患者的研究
6. Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients [O] . Bertrand Lioger, Soujanya Ratna Edupuganti, Denis Mulleman, 2017

机译：抗原负荷和血清IgG浓度影响类风湿关节炎患者的利妥昔单抗药代动力学
7. Effects of rituximab treatment on the serum concentrations of vitamin D and interleukins 2, 6, 7, and 10 in patients with rheumatoid arthritis [O] . Hasan, Eman, Olusi, Samuel, Al-Awadhi, Adel, 2012

机译：利妥昔单抗治疗对类风湿关节炎患者维生素D和白介素2、6、7和10的血药浓度的影响

Antigenic burden and serum IgG concentrations influence rituximab pharmacokinetics in rheumatoid arthritis patients

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