• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biotechnology and Bioengineering >Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway
【24h】

Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway

机译：GDP - 岩氧生物合成途径的Glycoengering调制IgG1免疫偶联功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract <section xml:id="bit26496-sec-0001" numbered="no"> > Cross‐linking of the Fcγ receptors expressed on the surface of hematopoietic cells by IgG immune complexes triggers the activation of key immune effector mechanisms, including antibody‐dependent cell mediated cytotoxicity (ADCC). A conserved N‐glycan positioned at the N‐terminal region of the IgG C <sub>H</sub> 2 domain is critical in maintaining the quaternary structure of the molecule for Fcγ receptor engagement. The removal of a single core fucose residue from the N‐glycan results in a considerable increase in affinity for FcγRIIIa leading to an enhanced receptor‐mediated immunoeffector function. The enhanced potency of the molecule translates into a number of distinct advantages in the development of IgG antibodies for cancer therapy. In an effort to significantly increase the potency of an anti‐CD20, IgG1 molecule, we selectively targeted the de novo GDP‐fucose biosynthesis pathway of the host CHO cell line to generate 80% afucosylated IgG1 resulting in enhanced FcγRIIIa binding (13‐fold) and in vitro ADCC cell‐based activity (11‐fold). In addition, this effective glycoengineering strategy also allowed for the utilization of the alternate GDP‐fucose salvage pathway to provide a fast and efficient mechanism to manipulate the N‐glycan fucosylation level to modulate IgG immune effector function. </section> </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <title type =“main”>抽象</ title> <section XML：ID =“bit26496-sec-0001”编号=“否”> >通过IgG免疫复合物在造血细胞表面表达的Fcγ受体的交联触发了关键免疫效应机制的激活，包括依赖依赖性细胞介导的抗体依赖性细胞细胞毒性（ADCC）。定位在IgG C <Sub> H </ sub> 2结构域的N-末端区域的保守的N-聚糖对于维持分子的季结构至关重要，用于FCγ受体接合。从N-聚糖中除去单芯岩藻糖残基导致对FcγRIIIA的亲和力相当大的增加，导致增强的受体介导的免疫切除函数。分子的增强效力转化为癌症治疗IgG抗体的许多不同的优点。努力显着增加抗CD20，IgG1分子的效力，我们选择性地靶向宿主Cho细胞系的De Novo GDP - 岩藻糖生物合成途径，以产生＆ 80％的抑制剂，导致增强的FcγRIIIa结合（13-折叠）和体外ADCC基于细胞的活性（11倍）。此外，这种有效的甘油化策略还允许利用交替的GDP - 岩藻糖挽救途径，以提供快速有效的机制，以操纵N-聚糖岩藻糖基化水平以调节IgG免疫效应功能。 </ p> </ section> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-15017/'>《Biotechnology and Bioengineering》</a> <b style="margin: 0 2px;">|</b><span>2018年第3期</span><b style="margin: 0 2px;">|</b><span>共14页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kelly Ronan M.&option=202" target="_blank" rel="nofollow">Kelly Ronan M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kowle Ronald L.&option=202" target="_blank" rel="nofollow">Kowle Ronald L.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lian Zhirui&option=202" target="_blank" rel="nofollow">Lian Zhirui;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Strifler Beth A.&option=202" target="_blank" rel="nofollow">Strifler Beth A.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Witcher Derrick R.&option=202" target="_blank" rel="nofollow">Witcher Derrick R.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Parekh Bhavin S.&option=202" target="_blank" rel="nofollow">Parekh Bhavin S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Wang Tongtong&option=202" target="_blank" rel="nofollow">Wang Tongtong;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Frye Christopher C.&option=202" target="_blank" rel="nofollow">Frye Christopher C.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> <p>Biotechnology Discovery Research Lilly Research Laboratories Eli Lilly and CompanyLilly Corporate CenterIndianapolis Indiana;</p> <p>Biotechnology Discovery Research Lilly Research Laboratories Eli Lilly and CompanyLilly Corporate CenterIndianapolis Indiana;</p> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> <p>Bioprocess Research and DevelopmentEli Lilly and CompanyIndianapolis Indiana;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/180.html" title="生物工程学（生物技术）">生物工程学（生物技术）;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=ADCC&option=203" rel="nofollow">ADCC;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=afucosylation&option=203" rel="nofollow">afucosylation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=FcγRIIIa&option=203" rel="nofollow">FcγRIIIa;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=glycoengineering&option=203" rel="nofollow">glycoengineering;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=mAb&option=203" rel="nofollow">mAb;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=N‐glycan&option=203" rel="nofollow">N‐glycan;</a> </p> <div class="translation"> 机译：ADCC;afucosylation;fcγRIIIA;Glycoengineering;mab;n-甘草; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704021882015.html">Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kelly Ronan M.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kelly Ronan M.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kowle Ronald L.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Kowle Ronald L.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lian Zhirui&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Lian Zhirui,</a> <a href="/journal-foreign-15017/" target="_blank" rel="nofollow" class="tuijian_authcolor">Biotechnology and Bioengineering .</a> <span>2018</span><span>,第3期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：GDP - 岩氧生物合成途径的Glycoengering调制IgG1免疫偶联功能</span> </p> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_applied-microbiology-biotechnology_thesis/020419468782.html">Modulation of guanosine nucleotides biosynthetic pathways enhanced GDP-l-fucose production in recombinant Escherichia coli</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Won-Heong Lee&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Won-Heong Lee,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=So-Yeon Shin&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">So-Yeon Shin,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Myoung-Dong Kim&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Myoung-Dong Kim,</a> <a href="/journal-foreign-7887/" target="_blank" rel="nofollow" class="tuijian_authcolor">Applied Microbiology and Biotechnology .</a> <span>2012</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：鸟嘌呤核苷酸生物合成途径的调控增强了重组大肠杆菌中GDP-1-岩藻糖的生产</span> </p> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-foreign_detail_thesis/0204121373436.html">Two Pathways for Importing GDP-fucose into the Endoplasmic Reticulum Lumen Function Redundantly in the O-Fucosylation of Notch in Drosophila</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiroyuki O. Ishikawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hiroyuki O. Ishikawa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tomonori Ayukawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tomonori Ayukawa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Minoru Nakayama&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Minoru Nakayama,</a> <a href="/journal-foreign-33692/" target="_blank" rel="nofollow" class="tuijian_authcolor">The Journal of biological chemistry .</a> <span>2010</span><span>,第6期</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：两种途径将GDP - 岩藻糖导入内质网腔功能中，在果蝇的O-岩藻糖型中冗余</span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-conference-foreign_meeting-255460_thesis/0705015722989.html">The tumour microenvironment regulates components of the fucose biosynthesis pathways in colorectal cancer cells</a> <b>[C]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=V. LIFSHITZ&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">V. LIFSHITZ,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=L. CHEN-LEVI&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">L. CHEN-LEVI,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=A. ZIPIN-ROITMAN&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">A. ZIPIN-ROITMAN,</a> <a href="/conference-foreign-255460/" target="_blank" rel="nofollow" class="tuijian_authcolor">Falk Symposium .</a> <span>2007</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：肿瘤微环境调节结直肠癌细胞中岩藻糖生物合成途径的组分</span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-degree-foreign_mphd_thesis/02061393566.html">Analytical method development and the study of inhibitors for the GDP-mannose 4,6-dehydratase enzyme involved in GDP-fucose synthesis pathway.</a> <b>[D] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=McKee, Marianne Lynette.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">McKee, Marianne Lynette. </a> <span>2001</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：分析方法的开发和涉及GDP-岩藻糖合成途径的GDP-甘露糖4,6-脱水酶抑制剂的研究。</span> </p> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-journal-foreign-pmc_detail_thesis/04000695775.html">Two Pathways for Importing GDP-fucose into the Endoplasmic Reticulum Lumen Function Redundantly in the O-Fucosylation of Notch in Drosophila</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Hiroyuki O. Ishikawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Hiroyuki O. Ishikawa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tomonori Ayukawa&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Tomonori Ayukawa,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Minoru Nakayama&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Minoru Nakayama,</a> <span>2010</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：果蝇凹口O-岩藻糖基化中将GDP-岩藻糖导入内质网内腔功能的两种途径</span> </p> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/open-access_resources_thesis/0100036690315.html ">Two Pathways for Importing GDP-fucose into the Endoplasmic Reticulum Lumen Function Redundantly in the O-Fucosylation of Notch in Drosophila*</a> <b>[O] </b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ishikawa, Hiroyuki O.&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ishikawa, Hiroyuki O.,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ayukawa, Tomonori&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Ayukawa, Tomonori,</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nakayama, Minoru&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Nakayama, Minoru,</a> <span>2009</span> </span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：果蝇凹口的O-岩藻糖基化过程中将GDP-岩藻糖导入内质网腔功能的两种途径*</span> </p> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/academic-journal-cn_food-fermentation-industries_thesis/020123170975.html">高山被孢霉GDP-L-岩藻糖合成途径中GDP-甘露糖-4,6-脱水酶的克隆、表达和功能鉴定</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=王鸿超&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 王鸿超</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张陈&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,张陈</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=周昕&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,周昕</a> <span> <a href="/journal-cn-9397/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 食品与发酵工业 </a> </span> <span> . 2016</span><span>,第011期</span> </span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/academic-journal-cn_food-fermentation-industries_thesis/020123208410.html">海藻糖的生物合成途径及其生物学功能</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=宋晓丽&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 宋晓丽</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=石东升&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,石东升</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=温佳文&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,温佳文</a> <span> <a href="/journal-cn-9397/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 食品与发酵工业 </a> </span> <span> . 2013</span><span>,第008期</span> </span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-biology_thesis/0201255119022.html">类胡萝卜素的生物合成途径及生物学功能研究进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=韩利军&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 韩利军</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=阳成伟&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,阳成伟</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=欧志英&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,欧志英</a> <span> <a href="/journal-cn-5090/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物学杂志 </a> </span> <span> . 2002</span><span>,第006期</span> </span> </div> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/academic-journal-cn_journal-chinese-electron-microscopy-society_thesis/0201288861939.html">固醇合成途径关键基因SMT2、SMT3在植物免疫中的功能研究</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=钱虹萍&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 钱虹萍</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=林金星&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,林金星</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=崔亚宁&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,崔亚宁</a> <span> <a href="/journal-cn-8723/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 电子显微学报 </a> </span> <span> . 2021</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/academic-journal-cn_current-biotechnology_thesis/0201254973639.html">树莓酮生物合成途径及关键酶功能研究进展</a> <b>[J]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=张奋强&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 张奋强</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘欢&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,刘欢</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄丽娜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,黄丽娜</a> <span> <a href="/journal-cn-5083/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 生物技术进展 </a> </span> <span> . 2017</span><span>,第002期</span> </span> </div> </li> <li> <div> <b>6. </b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-17976_thesis/020221932370.html">丹参有效成分生物合成途径及关键功能基因组研究</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄璐琦&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄璐琦</a> <span> <a href="/conference-cn-17976/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 第二届中国天然药物研究与发展论坛 </a> <span> <span> . 2008</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020313354422.html">GDP-岩藻糖转运体生物学功能的基础研究</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=刘桐桐&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 刘桐桐</a> <span> . 2017</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113280282.html">通过发酵产生2-氧代己二酸的经改造的生物合成途径</a> <b>[P]</b> . <span> 中国专利： CN113330108A </span> <span> . 2021-08-31</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120101328137.html">一种特异性检测抗体-药物偶联物中偶联抗体的免疫原性生物分析方法</a> <b>[P]</b> . <span> 中国专利： CN110548568A </span> <span> . 2019-12-10</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130500250158.html">Enhanced production of 2'-fucosyllactose in Corynebacterium Glutamicum through introduction of fucosyllactose transporter and opimization of GDP-L-fucose biosynthetic pathway</a> <b>[P]</b> . <span> 外国专利： <!-- --> KR102268092B1 </span> <span> . 2021-06-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过引入岩藻糖糖苷转运蛋白和GDP-L-岩藻糖生物合成途径的优化，增强了棒状杆菌中的2'-岩氧树值糖苷的生产 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130499585970.html">Enhanced production of 2'-fucosyllactose in Corynebacterium Glutamicum through introduction of fucosyllactose transporter and opimization of GDP-L-fucose biosynthetic pathway</a> <b>[P]</b> . <span> 外国专利： <!-- --> KR20210028292A </span> <span> . 2021-03-12</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：通过引入岩藻糖糖苷转运蛋白和GDP-L-岩藻糖生物合成途径的优化，增强了棒状杆菌中的2'-岩氧树值糖苷的生产 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130406460193.html">BIOSYNTHESIS OF CMP-LEGIONAMINIC ACID FROM FRUCTOSE-6-P, AND RESPECTIVE PATHWAY INTERMEDIATES, USING NOVEL GDP-LINKED PRECURSORS</a> <b>[P]</b> . <span> 外国专利： <!-- --> CA2747214C </span> <span> . 2018-09-25</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：使用新型GDP关联前体从果糖6-P进行CMP豆蔻酸的生物合成以及特定的途径中间体 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704021882015','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" onclick="$('.journalsub-pop-up').hide()"> <p class="pardon">抱歉，该期刊暂不可订阅，敬请期待！</p> <p class="current">目前支持订阅全部北京大学中文核心（2020）期刊目录。</p> <div style="display: flex;margin-top: 69px;justify-content: space-between;"> <div class="no-sub" onclick="$('.journalsub-pop-up').hide()">暂不订阅</div> <div class="other-sub" onclick="continueSub('from=pc-detail')">继续订阅其他期刊</div> </div> </div> </div> <div class="right_btn"> <ul> <li class="gouwuche"> <!-- <a href="javascript:void(0);" onclick="link_analysis('/shoppingcart/auth/list.html',this)">购物车</a>--> </li> <li class="yijian"> <a href="javascript:void(0);" onclick="link_analysis('/mycenter/auth/complaint.html',this)">意见反馈</a> </li> <li class="top"> <a href="javascript:scrollTo(0,0);">回到顶部</a> </li> <li class="shouye"> <a href="/">回到首页</a> </li> </ul> </div> <div class="xllindexfooter"> <div class="xllindexfootercenter"> <div class="xllindexfooterleft left" > <div class="xllindexfooterleftli"> <ul> <li><a href="/about.html">关于掌桥</a></li> <li><a href="/help/helpmap.html">资源导航</a></li> <li><a href="/help/helpguide.html">新手指南</a></li> <li><a href="/help/helpcenter.html">常见问题</a></li> <li><a href="/sitemap.html">网站地图</a></li> <li><a href="/help/helpcenter.html?type=9">版权声明</a></li> </ul> </div> <div class="xllindexfooterleft"> <p class="xllindexfooterlefteamil">客服邮箱：kefu@zhangqiaokeyan.com</p> <div class="xllindexfooterlefttcp"> <div class="xllindexfooterpoliceiimg"></div> <div class="xllindexfooterpoliceispan"> <span>京公网安备：11010802029741号 </span> <span>ICP备案号：<a href="https://beian.miit.gov.cn" rel="nofollow" target="_blank">京ICP备15016152号-6</a></span> <span>六维联合信息科技 (北京) 有限公司©版权所有</span> </div> </div> </div> </div> <div class="xllindexfooterright left"> <ul> <li> <p style="font-weight: bold;">客服微信</p> <div></div> </li> <li> <p style="font-weight: bold;">服务号</p> <div></div> </li> </ul> </div> </div> </div> <span id="0704021882015down" data-source="7," data-out-id="3H0HMpHB/VK0eN5QOJH/bw==," data-f-source-id="7" data-title="Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway" data-price="20" data-site-name="" data-transnum="24" style="display:none;"></span> <input type="hidden" value="4" id="sourcetype"> <input type="hidden" value="15017" id="journalid"> <input type="hidden" value="1" id="inyn_provide_service_level"> <input type="hidden" value="https://cdn.zhangqiaokeyan.com" id="imgcdn"> <input type="hidden" value="1" id="isdeatail"> <input type="hidden" value="" id="syyn_indexed_database"> <input type="hidden" value="" id="servicetype"> <input type="hidden" id="pagename" value="Modulation of IgG1 immunoeffector function by glycoengineering of the GDP‐fucose biosynthesis pathway"/> <input type="hidden" value="thesis_get_original" id="pageIdentification"> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery-1.12.4.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/lwlh_ajax.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zq.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/common.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/jquery.cookie.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/top.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/tip.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/login.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/down.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/search.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/searchtype.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/user/regist.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/zxs_solor/detail.js?v=5.7.7"></script> <script type="text/javascript" src="https://www.zhangqiaokeyan.com/statistics/static/pagecollection.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/tj.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/pushbaidu.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/common/history.js"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/util/cookie.js?v=5.7.7"></script> <script type="text/javascript" src="https://cdn.zhangqiaokeyan.com/js/weipu/weipu.js?v=5.7.7"></script> </body> <script> $(function(){ var weiPuStatus = getCookie('WeiPuStatus'); if(weiPuStatus){ tipWeiPuStatus(weiPuStatus); delCookie('WeiPuStatus'); } getFacetKeywordVoInId(); var sourcetype = $("#sourcetype").val(); var inyn_provide_service_level = $("#inyn_provide_service_level").val(); if((sourcetype ==1||sourcetype==4)&&inyn_provide_service_level!=4){ getJournal(); } }) </script> </html>