Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi

Sena Bastos Daniel Silva; Miranda Bianca Meirelles; Fialho Martins Thais Viana; Guimaraes Ervilha Luiz Otavio; Ferreira Souza Ana Claudia; Emerick Sabrina de Oliveira; da Silva Adriana Carneiro; Novaes Romulo Dias; Neves Mariana Machado; Santos Eliziaria Cardoso; de Oliveira Leandro Licursi; Marques-da-Silva Eduardo de Almeida

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Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi

机译：脂磷酰基-3重组蛋白质疫苗控制肝寄生疫苗，并阻止由Leishmania Infantum Chagasi感染的小鼠组织损伤

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Aims: In this work, we aimed to evaluate the effects of the Leishmania infantum chagasi infection on the liver of vaccinated mice, considering parameters of tissue damage and the inflammatory response elicited by vaccination.

机译：目的：在这项工作中，我们旨在评估Leishmania Infantum ChaGasi感染对疫苗小鼠肝脏的影响，考虑组织损伤参数和疫苗接种引发的炎症反应。

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来源
《Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie》 |2020年第2020期|共10页
作者
Sena Bastos Daniel Silva; Miranda Bianca Meirelles; Fialho Martins Thais Viana; Guimaraes Ervilha Luiz Otavio; Ferreira Souza Ana Claudia; Emerick Sabrina de Oliveira; da Silva Adriana Carneiro; Novaes Romulo Dias; Neves Mariana Machado; Santos Eliziaria Cardoso; de Oliveira Leandro Licursi; Marques-da-Silva Eduardo de Almeida;
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作者单位

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Rural Rio de Janeiro Dept Anim Biol Rio De Janeiro RJ Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Alfenas Inst Biomed Sci Dept Struct Biol Alfenas MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Fed Univ Jequitinhonha &

Mucuri Valleys Sch Med Teofilo Otoni MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

Univ Fed Vicosa Dept Gen Biol Av PH Rolfs Campus Univ BR-36570900 Vicosa MG Brazil;

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原文格式 PDF
正文语种 eng
中图分类治疗学;
关键词
LPG3; Visceral leishmaniasis; Liver morphology; Oxidative stress; Vaccine;

机译：LPG3;内脏Leishmaniaisis;肝脏形态;氧化应激;疫苗;

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专利

1. Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi [J] . Sena Bastos Daniel Silva, Miranda Bianca Meirelles, Fialho Martins Thais Viana, Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie . 2020,第期

机译：脂磷酰基-3重组蛋白质疫苗控制肝寄生疫苗，并阻止由Leishmania Infantum Chagasi感染的小鼠组织损伤
2. Vaccination with the Leishmania infantum ribosomal proteins induces protection in BALB/c mice against Leishmania chagasi and Leishmania amazonensis challenge. [J] . Chavez Fumagalli MA, Costa MA, Oliveira DM, Microbes and infection . 2010,第12a13期

机译：用婴儿利什曼原虫核糖体蛋白进行疫苗接种可在BALB / c小鼠中诱导保护，使其免受南美白痢和利什曼原虫的攻击。
3. Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice [J] . Heitor Franco De Andrade Junior, Jo?o Alberto Osso Junior, Nanci Do Nascimento, Memórias do Instituto Oswaldo Cruz . 2013,第5期

机译：葡甲胺锑酸盐在健康和利什曼原虫（Leishmania）婴儿南美锥虫感染的BALB / c小鼠中的生物分布
4. Protein interactions at the biomaterial-tissue interface, the inescapable reality: understanding, preventing, controlling [C] . John L Brash World biomaterials congress . 2016

机译：生物材料与组织界面处的蛋白质相互作用，不可避免的现实：理解，预防，控制
5. The development of bioreactor protocols for the production of recombinant therapeutic proteins from genetically engineered parasite cells (Leishmania chagasi). [D] . Pollock, Aaron Ellsworth. 1999

机译：用于从基因工程寄生虫细胞（利什曼原虫chagasi）生产重组治疗性蛋白质的生物反应器规程的开发。
6. Use of a Recombinant Cysteine Proteinase from Leishmania (Leishmania) infantum chagasi for the Immunotherapy of Canine Visceral Leishmaniasis [O] . Josie Haydée Lima Ferreira, Lucilene dos Santos Silva, Ieda Maria Longo-Maugéri, 2014

机译：婴儿利什曼原虫（Leishmania）chagasi重组半胱氨酸蛋白酶在犬内脏利什曼病免疫治疗中的应用
7. Canine visceral leishmaniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs Leishmaniose visceral canina causada por Leishmania (L.) infantum chagasi na Amazônia brasileira: comparação da densidade parasitária da pele, linfonodo e vísceras entre cães soropositivos, sintomáticos e assintomáticos [O] . Luciana Vieira R. Lima, Liliane Almeida Carneiro, Marliane Batista Campos, 2010

机译：由于亚马逊巴西利什曼原虫（L.）infantum chagasi引起的犬内脏利什曼病：有症状和无症状犬之间皮肤，淋巴结和内脏组织的寄生虫密度比较，由利什曼原虫（L.）infantum chagasi na引起的血清阳性犬内脏利什曼病巴西亚马逊：血清阳性，症状性和无症状犬的皮肤，淋巴结和内脏寄生密度的比较

Lipophosphoglycan-3 recombinant protein vaccine controls hepatic parasitism and prevents tissue damage in mice infected by Leishmania infantum chagasi

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