Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

Sato Kota; Shiga Yukihiro; Nakagawa Yurika; Fujita Kosuke; Nishiguchi Koji M.; Tawarayama Hiroshi; Murayama Namie; Maekawa Shigeto; Yabana Takeshi; Omodaka Kazuko; Katayama Shota; Feng Qiwei; Tsuda Satoru; Nakazawa Toru

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Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

机译：eCel1与AAV2介导的CRISPR / CAS9系统促进了视鼠视网膜中的视神经损伤的RGC死亡

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PURPOSE. To assess the therapeutic potential of endothelin-converting enzyme-like 1 (Ecel1) in a mouse model of optic nerve crush.

机译：目的。评估内皮素转换酶样1（eCel1）的治疗潜力在视神经挤压的小鼠模型中。

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来源
《Investigative ophthalmology & visual science》 |2018年第10期|共9页
作者
Sato Kota; Shiga Yukihiro; Nakagawa Yurika; Fujita Kosuke; Nishiguchi Koji M.; Tawarayama Hiroshi; Murayama Namie; Maekawa Shigeto; Yabana Takeshi; Omodaka Kazuko; Katayama Shota; Feng Qiwei; Tsuda Satoru; Nakazawa Toru;
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作者单位

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Retinal Dis Control Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Adv Ophthalm Med Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

Tohoku Univ Dept Ophthalmol Grad Sch Med Sendai Miyagi Japan;

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原文格式 PDF
正文语种 eng
中图分类眼科学;
关键词
Ecel1; optic nerve injury; retinal ganglion cells; neuroprotection;

机译：ecel1;视神经损伤;视网膜神经节细胞;神经保护;

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专利

1. Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina [J] . Kota Sato, Yukihiro Shiga, Yurika Nakagawa, Investigative ophthalmology & visual science . 2018,第10期

机译：利用AAV2介导的CRISPR / Cas9系统进行Ecel1敲低可促进小鼠视网膜中视神经损伤引起的RGC死亡
2. Essential function of NHE8 in mouse retina demonstrated by AAV-mediated CRISPR/Cas9 knockdown [J] . Xia Chun-hong, Ferguson Ian, Li Mei, Experimental Eye Research . 2018,第期

机译：NHE8在小鼠视网膜中NHE8的基本功能通过AAV介导的CRISPR / CAS9敲低
3. AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury [J] . Robert W. Nickells, Heather M. Schmitt, Margaret E. Maes, Investigative ophthalmology & visual science . 2017,第14期

机译：AAV2介导的视神经损伤后小鼠视网膜的转导。
4. 3D papillary image capturing by the stereo fundus camera system for clinical diagnosis on retina and optic nerve [C] . Danilo A Motta, Andre Serillo, Luciana de Matos, Design and quality for biomedical technologies VII . 2014

机译：立体眼底摄像系统捕获3D乳头图像，用于视网膜和视神经的临床诊断
5. AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury [O] . Robert W. Nickells, Heather M. Schmitt, Margaret E. Maes, -1

机译：AAV2介导的视神经损伤后小鼠视网膜的转导。
6. AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury [O] . Robert W. Nickells, Heather M. Schmitt, Margaret E. Maes, 2017

机译：AAV2介导的小鼠视网膜转导后视神经损伤后的转导

Ecel1 Knockdown With an AAV2-Mediated CRISPR/Cas9 System Promotes Optic Nerve Damage-Induced RGC Death in the Mouse Retina

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