Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

Sagara Issaka; Beavogui Abdoul Habib; Zongo Issaka; Soulama Issiaka; Borghini-Fuhrer Isabelle; Fofana Bakary; Traore Aliou; Diallo Nouhoum; Diakite Hamadoun; Togo Amadou H.; Koumare Sekou; Keita Mohamed; Camara Daouda; Some Anyirekun F.; Coulibaly Aboubacar S.; Traore Oumar B.; Dama Souleymane; Goita Siaka; Djimde Moussa; Bamadio Amadou; Dara Niawanlou; Maiga Hamma; Sidibe Bouran; Dao Francois; Coulibaly Moctar; Alhousseini Mohamed Laraine; Niangaly Hamidou; Sangare Boubou; Diarra Modibo; Coumare Samba; Kabore Moise J. T.; Ouattara San Maurice; Barry Aissata; Kargougou Desire; Diarra Amidou; Henry Noelie; Sore Harouna; Bougouma Edith C.; Thera Ismaila; Compaore Yves D.; Sutherland Colin J.; Sylla Malick Minkael; Nikiema Frederic; Diallo Mamadou Saliou; Dicko Alassane; Picot Stephane; Borrmann Steffen; Duparc Stephan; Miller Robert M.; Doumbo Ogobara K.; Shin Jangsik; Gil Jose Pedro; Bjoerkman Anders; Ouedraogo Jean-Bosco; Sirima Sodiomon B.; Djimde Abdoulaye A.

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Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

机译：Pyronaridine-artesunate或二氢氨基氨苄蛋白 - 波动与电流的一线疗法，用于反复治疗简单的疟疾：随机，多期中心，开放标签，纵向，控制，第3B / 4次试验

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Background Arte

机译：背景技术

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来源
《The Lancet》 |2018年第10128期|共13页
作者
Sagara Issaka; Beavogui Abdoul Habib; Zongo Issaka; Soulama Issiaka; Borghini-Fuhrer Isabelle; Fofana Bakary; Traore Aliou; Diallo Nouhoum; Diakite Hamadoun; Togo Amadou H.; Koumare Sekou; Keita Mohamed; Camara Daouda; Some Anyirekun F.; Coulibaly Aboubacar S.; Traore Oumar B.; Dama Souleymane; Goita Siaka; Djimde Moussa; Bamadio Amadou; Dara Niawanlou; Maiga Hamma; Sidibe Bouran; Dao Francois; Coulibaly Moctar; Alhousseini Mohamed Laraine; Niangaly Hamidou; Sangare Boubou; Diarra Modibo; Coumare Samba; Kabore Moise J. T.; Ouattara San Maurice; Barry Aissata; Kargougou Desire; Diarra Amidou; Henry Noelie; Sore Harouna; Bougouma Edith C.; Thera Ismaila; Compaore Yves D.; Sutherland Colin J.; Sylla Malick Minkael; Nikiema Frederic; Diallo Mamadou Saliou; Dicko Alassane; Picot Stephane; Borrmann Steffen; Duparc Stephan; Miller Robert M.; Doumbo Ogobara K.; Shin Jangsik; Gil Jose Pedro; Bjoerkman Anders; Ouedraogo Jean-Bosco; Sirima Sodiomon B.; Djimde Abdoulaye A.;
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作者单位

Ctr Format &

Rech Sante Rurale Maferinyah Conakry Guinea;

Inst Rech Sci Sante Bobo Dioulasso Burkina Faso;

Natl Ctr Res &

Training Malaria Ouagadougou Burkina Faso;

Karolinska Inst Dept Physiol &

Pharmacol Stockholm Sweden;

Med Malaria Venture Geneva Switzerland;

Karolinska Inst Dept Physiol &

Pharmacol Stockholm Sweden;

Univ Tubingen Inst Trop Med Tubingen Germany;

Univ Tubingen Inst Trop Med Tubingen Germany;

Artemida Pharma Stevenage Herts England;

German Ctr Infect Tubingen Germany;

London Sch Hygiene &

Torp Med London England;

Pharmaceut Co Seoul South Korea;

Hosp Civils Lyon Lyon France;

Univ Lyon Malaria Res Univ UMR 5246 Lyon France;

Karolinska Inst Dept Microbiol Tumor &

Cell Biol Stockholm Sweden;

Univ Sci Techn andTechnol Bamako Fac Pharm Malaria Res andTraining Ctr Dept Epidemiol Parasit;

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正文语种 eng
中图分类医药、卫生;
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1. Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial [J] . Sagara Issaka, Beavogui Abdoul Habib, Zongo Issaka, The Lancet . 2018,第10128期

机译：Pyronaridine-artesunate或二氢氨基氨苄蛋白 - 波动与电流的一线疗法，用于反复治疗简单的疟疾：随机，多期中心，开放标签，纵向，控制，第3B / 4次试验
2. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial (vol 18, pg 672, 2017) [J] . Garcia-Donas J., Font A., Perez-Valderrama B. The lancet oncology . 2019,第1期

机译：Vinflunine的维护疗法加上最佳支持性护理与单独的尿路上皮癌患者的最佳支持性护理（Maja; Sogug 2011/02）：多期，随机，受控，开放标签，第2期试验（Vol 18，PG 672,2017）
3. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial [J] . Garcia-Donas Jesus, Font Albert, Perez-Valderrama Begona, The lancet oncology . 2017,第5期

机译：Vinflunine的维护疗法加上最佳支持性护理与单独的尿路上皮癌患者的最佳支持性护理（Maja; Sogug 2011/02）：多期，随机，受控，开放标签，第2期试验
4. Laser Therapy in the Treatment of Achilles Tendinopathy: A Randomised Controlled Trial [C] . Steve Tumilty MPhty, Joanne Munn PhD, J. Haxby Abbott PhD, International Laser Medicine Congress . 2010

机译：激光治疗治疗Achilles肌腱病变：随机对照试验
5. Pyronaridine–artesunate or dihydroartemisinin–piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised multicentre open-label longitudinal controlled phase 3b/4 trial [O] . Issaka Sagara, Abdoul Habib Beavogui, Issaka Zongo, -1

机译：吡咯烷-青蒿琥酯或二氢青蒿素-哌喹与目前用于重复治疗简单并发症的一线疗法的比较：一项随机多中心开放标签纵向对照3b / 4期试验
6. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial [O] . Jesus García-Donas, Albert Font, Begoña Pérez-Valderrama, 2017

机译：Vinflunine加上血管内癌的维护治疗与先进的尿路上皮癌的患者相比，在一线化疗后的反应（Maja; Sogug 2011/02）：多期，随机，受控，开放标签，第2阶段试验中的最佳支持性护理

Pyronaridine-artesunate or dihydroartemisinin-piperaquine versus current first-line therapies for repeated treatment of uncomplicated malaria: a randomised, multicentre, open-label, longitudinal, controlled, phase 3b/4 trial

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