Hepatocellular carcinoma

摘要

In their Seminar on hepatocellular carcinoma, Alejandro Forner and colleagues question the conclusions of our Cochrane systematic review.2 We could not identify evidence to show that transarterial (chemo)embolisation (TAE/TACE) has a beneficial effect on survival in patients with unresectable hepatocellular carcinoma. Using trial sequential analyses, we also showed that additional patients might be needed to reach firm evidence to accept or refute the superiority of TAE/TACE over no intervention.