Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

Golan Talia; Hammel Pascal; Reni Michele; Van Cutsem Eric; Macarulla Teresa; Hall Michael J.; Park Joon-Oh; Hochhauser Daniel; Arnold Dirk; Oh Do-Youn; Reinacher-Schick Anke; Tortora Giampaolo; Alguel Hana; OReilly Eileen M.; McGuinness David; Cui Karen Y.; Schlienger Katia; Locker Gershon Y.; Kindler Hedy L.

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Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

机译：用于种系BRCA-突变的转移性胰腺癌的维护olaparib

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BackgroundPatients with a germline BRCA1 or BRCA2 mutation make up a small subgroup of those with metastatic pancreatic cancer. The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor olaparib has had antitumor activity in this population.

机译：具有种系BRCA1或BRCA2突变的背景性构成具有转移性胰腺癌的小亚组。聚（腺苷二磷酸核糖核糖）聚合酶（PARP）抑制剂Olaparib在该群体中具有抗肿瘤活性。

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来源
《The New England journal of medicine》 |2019年第4期|共11页
作者
Golan Talia; Hammel Pascal; Reni Michele; Van Cutsem Eric; Macarulla Teresa; Hall Michael J.; Park Joon-Oh; Hochhauser Daniel; Arnold Dirk; Oh Do-Youn; Reinacher-Schick Anke; Tortora Giampaolo; Alguel Hana; OReilly Eileen M.; McGuinness David; Cui Karen Y.; Schlienger Katia; Locker Gershon Y.; Kindler Hedy L.;
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作者单位

Tel Aviv Univ Sheba Med Ctr Oncol Inst IL-52621 Tel Aviv Israel;

Hop Beaujon AP HP Clichy France;

IRCCS Osped San Raffaele Sci Inst Milan Italy;

Univ Hosp Gasthuisberg Leuven Belgium;

Vall dHebron Univ Hosp Barcelona Spain;

Fox Chase Canc Ctr 7701 Burholme Ave Philadelphia PA 19111 USA;

Sungkyunkwan Univ Sch Med Samsung Med Ctr Seoul South Korea;

UCL Canc Inst London England;

Asklepios Tumorzentrum Hamburg Asklepios Klin Alt Hamburg Germany;

Seoul Natl Univ Seoul Natl Univ Hosp Coll Med Canc Res Inst Seoul South Korea;

Ruhr Univ Bochum St Josef Hosp Bochum Germany;

Azienda Osped Univ Integrata Verona Verona Italy;

Tech Univ Munich Klinikum Rechts Isar Dept Internal Med 2 Munich Germany;

Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY 10021 USA;

AstraZeneca Cambridge England;

AstraZeneca Gaithersburg MD USA;

Merck Kenilworth NJ USA;

AstraZeneca Gaithersburg MD USA;

Univ Chicago Chicago IL 60637 USA;

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正文语种 eng
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专利

1. Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer [J] . Golan Talia, Hammel Pascal, Reni Michele, The New England journal of medicine . 2019,第4期

机译：用于种系BRCA-突变的转移性胰腺癌的维护olaparib
2. Olaparib for Metastatic Germline BRCA-Mutated Breast Cancer [J] . Narod Steven, Booth Christopher M., Foulkes William D. The New England journal of medicine . 2017,第18期

机译：Olaparib用于转移种系BRCA-突变的乳腺癌
3. Cost-Effectiveness Analysis of Maintenance Olaparib in Patients with Metastatic Pancreatic Cancer and a Germline BRCA1/2 Mutation Based on the POLO Trial [J] . Mei Zhan, Hanrui Zheng, Yu Yang, Cancer Management and Research . 2020,第3期

机译：转移性胰腺癌患者维持奥拉帕的成本效果分析及基于POLO试验的种系BRCA1 / 2突变
4. Fluorescent humanized anti-CEA antibody specifically labels metastatic pancreatic cancer in a patient-derived orthotopic xenograft (PDOX) mouse model [C] . Thinzar M. Lwin, Kentaro Miyake, Takashi Murakami, Molecular-Guided Surgery: Molecules, Devices, and Applications IV . 2018

机译：荧光人源化抗CEA抗体在源自患者的原位异种移植（PDOX）小鼠模型中特异性标记转移性胰腺癌
5. The role of oncogenic Kras in pancreatic cancer progression and maintenance. [D] . Collins, Meredith Anne. 2014

机译：致癌性Kras在胰腺癌进展和维持中的作用。
6. Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic [O] . Na Li, Huanrui Zheng, Yanlei Huang, 2021

机译：种系BRCA突变转移性胰腺癌olaparib维持治疗的成本效果分析
7. Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic Cancer [O] . Na Li, Huanrui Zheng, Yanlei Huang, 2021

机译：种系BRCA突变转移性胰腺癌Olaparib维持治疗的成本效果分析

Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer

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