Mechanisms of anaphylaxis in human low-affinity IgG receptor locus knock-in mice

摘要

Background: Anaphylaxis can proceed through distinct IgE- or IgG-dependent pathways, which have been investigated in various mouse models. We developed a novel mouse strain in which the human low-affinity IgG receptor locus, comprising both activating (hFc gamma RIIA, hFc gamma RIIIA, and hFc gamma RIIIB) and inhibitory (hFc gamma RIIB) hFc gamma R genes, has been inserted into the equivalent murine locus, corresponding to a locus swap.