Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation

Villazala-Merino Sergio; Rodriguez-Dominguez Azahara; Stanek Victoria; Campion Nicholas J.; Gattinger Pia; Hofer Gerhard; Froeschl Renate; Fae Ingrid; Lupinek Christian; Vrtala Susanne; Breiteneder Heimo; Keller Walter; Perkmann Thomas; Nakamura Ryosuke; Pickl Winfried F.; Valenta Rudolf; Eckl-Dorna Julia; Niederberger Verena

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Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation

机译：特异性IgE含量和IgE-过敏原复合物与交联的能力确定CD23介导的T细胞活化程度

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Background: CD23 mediates IgE-facilitated allergen presentation and subsequent allergen-specific T-cell activation in allergic patients.

机译：背景：CD23介导IGE促进的过敏原呈递和随后的过敏寿特异性T细胞活化在过敏患者中。

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来源
《The Journal of Allergy and Clinical Immunology》 |2020年第3期|共15页
作者
Villazala-Merino Sergio; Rodriguez-Dominguez Azahara; Stanek Victoria; Campion Nicholas J.; Gattinger Pia; Hofer Gerhard; Froeschl Renate; Fae Ingrid; Lupinek Christian; Vrtala Susanne; Breiteneder Heimo; Keller Walter; Perkmann Thomas; Nakamura Ryosuke; Pickl Winfried F.; Valenta Rudolf; Eckl-Dorna Julia; Niederberger Verena;
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作者单位

Med Univ Vienna Dept Otorhinolaryngol Vienna Austria;

Med Univ Vienna Div Immunopathol Vienna Austria;

Med Univ Vienna Dept Otorhinolaryngol Vienna Austria;

Med Univ Vienna Dept Otorhinolaryngol Vienna Austria;

Med Univ Vienna Div Immunopathol Vienna Austria;

Karl Franzens Univ Graz Inst Mol Biosci BioTechMed Graz Graz Austria;

Med Univ Vienna Dept Lab Med Vienna Austria;

Med Univ Vienna Dept Blood Grp Serol &

Transfus Med Vienna Austria;

Med Univ Vienna Div Immunopathol Vienna Austria;

Med Univ Vienna Div Immunopathol Vienna Austria;

Med Univ Vienna Div Med Biotechnol Dept Pathophysiol &

Allergy Res Ctr Pathophysiol Infectiol &

Karl Franzens Univ Graz Inst Mol Biosci BioTechMed Graz Graz Austria;

Med Univ Vienna Dept Lab Med Vienna Austria;

Natl Inst Hlth Sci Div Med Safety Sci Kawasaki Kanagawa Japan;

Med Univ Vienna Inst Immunol Ctr Pathophysiol Infectiol &

Immunol Vienna Austria;

Med Univ Vienna Div Immunopathol Vienna Austria;

Med Univ Vienna Dept Otorhinolaryngol Vienna Austria;

Med Univ Vienna Dept Otorhinolaryngol Vienna Austria;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Allergen; CD23; Bet v 1; facilitated allergen presentation; IgE; birch pollen allergy; cross-linking; T-cell activation; IgE-allergen complex;

机译：过敏原;CD23;BET V 1;促进过敏原;IgE;桦树花粉过敏;交联;T细胞活化;IgE-过敏原复合物;

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专利

1. Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation [J] . Villazala-Merino Sergio, Rodriguez-Dominguez Azahara, Stanek Victoria, The Journal of Allergy and Clinical Immunology . 2020,第3期

机译：特异性IgE含量和IgE-过敏原复合物与交联的能力确定CD23介导的T细胞活化程度
2. Rhinovirus infection in atopic asthma increases peripheral IgE plus memory B cells and serum IgE levels despite reduced allergen-specific IgE [J] . Upton N., Wu Y. C., Dhariwal J., Clinical and experimental allergy : . 2015,第2期

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3. Increased plasma reactive oxidant levels and their relationship to blood cells, total IgE, and allergen-specific IgE levels in asthmatic children. [J] . Heidenfelder B, Johnson M, Hudgens E, The journal of asthma . 2010,第1期

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6. CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake as well as activation of allergen-specific T cells [O] . Regina Selb, Julia Eckl-Dorna, Alina Neunkirchner, -1

机译：B细胞上的CD23表面密度与IgE水平相关并确定IgE促进的过敏原摄取以及激活过敏原特异性T细胞
7. CD23 surface density on B cells is associated with IgE levels and determines IgE-facilitated allergen uptake, as well as activation of allergen-specific T cells [O] . Regina Selb, Julia Eckl-Dorna, Alina Neunkirchner, 2017

机译：B细胞上的CD23表面密度与IgE水平相关，并确定IgE促进的过敏原摄取，以及过敏原特异性T细胞的活化

Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation

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