Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy

Boonpiyathad Tadech; van de Veen Willem; Wirz Oliver; Sokolowska Milena; Ruckert Beate; Tan Ge; Sangasapaviliya Atik; Pradubpongsa Panitan; Fuengthong Rattanaporn; Thantiworasit Pattarawat; Sirivichayakul Sunee; Ruxrungtham Kiat; Akdis Cezmi A.; Akdis Mubeccel

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Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy

机译：特异性B细胞在2年内尘埃螨特异性免疫疗法中的免疫耐受性的作用

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Background: Long-term follow-up of allergen-specific B cells in terms of immunoglobulin isotype expression, plasmablast differentiation, and regulatory B (Breg) cell development during allergen-specific immunotherapy (AIT) has not been reported.

机译：背景技术尚未报道尚未报道过敏原特异性免疫疗法（AIT）的免疫球蛋白同种型表达，血浆血糖类同种型表达，血浆沸腾分化和调节B（BREG）细胞发育的长期随访。

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来源
《The Journal of Allergy and Clinical Immunology》 |2019年第3期|共20页
作者
Boonpiyathad Tadech; van de Veen Willem; Wirz Oliver; Sokolowska Milena; Ruckert Beate; Tan Ge; Sangasapaviliya Atik; Pradubpongsa Panitan; Fuengthong Rattanaporn; Thantiworasit Pattarawat; Sirivichayakul Sunee; Ruxrungtham Kiat; Akdis Cezmi A.; Akdis Mubeccel;
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作者单位

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Phramongkutklao Hosp Dept Med Bangkok Thailand;

Phramongkutklao Hosp Dept Med Bangkok Thailand;

Phramongkutklao Hosp Dept Med Bangkok Thailand;

Chulalongkorn Univ Fac Med Bangkok Thailand;

Chulalongkorn Univ Fac Med Bangkok Thailand;

Chulalongkorn Univ Fac Med Bangkok Thailand;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

Univ Zurich Swiss Inst Allergy &

Asthma Res SIAF Davos Switzerland;

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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
Allergen-specific immunotherapy; house dust mite; B cells; plasmablasts; immunoglobulin isotype; IgG(4); IgA; regulatory B cells; IL-10; IL-1 receptor antagonist; immune tolerance;

机译：特异性免疫疗法;房屋尘螨;B细胞;Plasmablasts;免疫球蛋白同种型;IgG（4）;IgA;调节B细胞;IL-10;IL-1受体拮抗剂;免疫耐受性;免疫耐受性;

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专利

1. Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy [J] . Boonpiyathad Tadech, van de Veen Willem, Wirz Oliver, The Journal of Allergy and Clinical Immunology . 2019,第3期

机译：特异性B细胞在2年内尘埃螨特异性免疫疗法中的免疫耐受性的作用
2. Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma [J] . Chuang-Ming Wang, Chia-Bin Chang, Michael WY Chan, 细胞与分子免疫学：英文版 . 2018,第011期

机译：特异性螨虫过敏原特异性免疫疗法增加了IL4 DNA甲基化，并在过敏性哮喘的儿童中诱导Der P特异性T细胞耐受性
3. Prenatal exposure to house dust mite allergen (Der p 1), cord blood T cell phenotype and cytokine production and atopic dermatitis during the first year of life. [J] . Hagendorens MM, Ebo DG, Bridts CH, Pediatric allergy and immunology: official publication of the European Society of Pediatric Allergy and Immunology . 2004,第4期

机译：在出生后第一年，产前暴露于屋尘螨过敏原（Der p 1），脐血T细胞表型和细胞因子产生以及特应性皮炎。
4. Immunotherapy in preneoplastic disease: targeting early procarcinogenic inflammatory changes that lead to immune suppression and tumor tolerance [C] . Bridget Keenan, Elizabeth M. Jaffee International Cancer Vaccine Symposium . 2013

机译：肺塑性疾病的免疫疗法：靶向早期促进炎症性能，导致免疫抑制和肿瘤耐受性
5. The role of T cell-associated polarizing transcription factors in dendritic cell priming of T cells towards immunity or tolerance; role of T-bet or Foxp3 ectopic expression in dendritic cells. [D] . Lipscomb, Michael Wheeler. 2009

机译：T细胞相关的极化转录因子在T细胞树突细胞引发免疫或耐受中的作用； T-bet或Foxp3异位表达在树突状细胞中的作用
6. Dust mite allergen-specific immunotherapy increases IL4 DNA methylation and induces Der p-specific T cell tolerance in children with allergic asthma [O] . Chuang-Ming Wang, Chia-Bin Chang, Michael WY Chan, 2018

机译：尘螨过敏原特异性免疫疗法可增强过敏性哮喘患儿的IL4 DNA甲基化并诱导Der p特异性T细胞耐受
7. Role of Der p 1–specific B cells in immune tolerance during 2 years of house dust mite–specific immunotherapy [O] . Tadech Boonpiyathad, Willem van de Veen, Oliver Wirz, 2019

机译：特异性B细胞在2年内尘埃螨特异性免疫疗法中的免疫耐受性的作用

Role of Der p 1-specific B cells in immune tolerance during 2 years of house dust mite-specific immunotherapy

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